Hybrid nerve sheath tumor
Hybrid nerve sheath tumors are uncommon, and most commonly encountered in the setting of neurofibromatosis type 1 or neurofibromatosis type 2. They represent benign peripheral nerve sheath tumors with combined histological features. The recognized combinations are 1:
- schwannoma + perineurioma (usually sporadic)
- schwannoma + neurofibroma (usually in the setting of NF1 or NF2)
- neurofibroma + perineurioma (rare, usually in the setting of NF1)
Hybrid nerve sheath tumors usually arise from peripheral nerve sheath tumors, rarely seen involving cranial nerves or spinal nerves 1.
- 1. Louis DN, Ohgaki H, Wiestler OD, Cavenee WK "WHO Classification of Tumours of the Central Nervous System. 4th Edition Revised" ISBN: 9789283244929