Hydroxyapatite deposition disease

Hydroxyapatite crystal deposition disease (HADD) is a disease of uncertain etiology characterized by periarticular and intra-articular deposition of hydroxyapatite (HA) crystals.

The shoulder is the most frequently involved site with classic calcific tendinitis presentation.  

HADD is most commonly found in middle-aged individuals.

Localized pain is one of the primary manifestations of the disease, associated with swelling, tenderness, and variable limitation of joint motion. Often asymptomatic.

The exact etiology has not been described; however, it is believed to be related to repeated trauma. 

The disease is characterized by calcium phosphate (calcium hydroxyapatite) crystal deposition in the periarticular soft tissues, especially in the tendons (best recognized as calcific tendinitis).

Most frequently it involves the shoulder joint, where crystal deposition occurs in the supraspinatus tendon, but the disease can affect numerous other sites as well. Calcific periarthritis or enthesitis would be the most appropriate term for this condition, as it occurs most commonly in the bony attachment of tendon near the joints 1.

HADD can affect other tendons of the body, such as the gluteus medius tendon, or along the femur, as well as at various sites of tendinous attachments (e.g. elbow, wrist, hand, knee, ankle, foot, and spine) 2.

Calcifications of varying sizes and shapes can involve the para-articular tendons, bursae, and capsule. The disease can be mono- or polyarticular.

It appears as homogeneous, round-to-ovoid calcification in the soft tissue with well-defined or ill-defined margins. The most characteristic lesions are seen in the shoulder with supraspinatus and biceps tendon involvement, adjacent to the greater tubercle and the glenoid tubercle, respectively, where these tendons attach.

Deposits within the infraspinatus and teres minor tendons are not uncommon and can be seen adjacent to the greater tuberosity on internal rotation or axillary views 1

Treatment is chiefly conservative, including NSAIDs, local heat application, and physiotherapy. Local corticosteroid injections may also be of benefit. 

Surgical removal of calcifications may be appropriate for cases refractory to other attempts of conservative treatment.

Ultrasound ablation may prove to be of short-term benefit in particular cases. However, its long-term benefit has not yet been demonstrated 3.

When intra-articular, HA crystals can cause joint destruction. Any joint can be involved; the shoulder is most commonly affected, resulting in Milwaukee shoulder syndrome 4. 

The differential diagnosis of joint pain with calcification is extensive and occurs in many conditions such as:

Another consideration for a calcific opacity in proximity to a joint (typically knee, elbow, etc.) would be a loose body from an osteochondritis dissecans (OCD) donor site. Therefore, radiographic findings, a thorough history, as well as physical examination, appropriate lab tests and additional imaging modalities, should be utilized to identify the most likely etiology 5.

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Article information

rID: 26978
Section: Gamuts
Synonyms or Alternate Spellings:
  • HADD
  • HADD deposition
  • Hydroxyapatite deposition disease (HADD)

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Cases and figures

  • Case 1: Milwaukee shoulder
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  • Case 2: gluteus medius calcific tendonitis
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  • Case 3: infraspinatus calcific tendonitis
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  • Case 4: calcific bursitis
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  • Case 5: longus colli calcific tendonitis
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  • Case 6: iliopsoas calcific tendinitis
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  • Case 7: longus colli calcific tendinitis
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