Inferior vena caval thrombosis

Inferior vena caval (IVC) thrombosis is an essential diagnosis while evaluating any neoplastic lesion, or portal hypertension. It is also important to differentiate bland thrombus from tumor thrombus.

Patient can present with many features which include

IVC thrombus can be classified under two broad headings:

  1. bland thrombus
  2. tumor thrombus

Bland thrombus can be an isolated thrombus. However, it commonly arises from deep vein thrombosis of the lower extremities.

  • hypercoagulable states
  • venous stasis
  • compression by neoplastic lesions, lymph nodes, retroperitoneal masses/fibrosis or hemorrhage
  • foreign bodies: vena cava filter, catheters
  • extension from benign tumors: angiomyolipoma, IVC leiomyoma, adrenal pheochromocytoma
  • traumatic liver injury: very rare 4

While any neoplastic lesion can cause IVC thrombosis, renal cell carcinoma is the most common malignancy to extend into the IVC 1. Other tumors that have a tendency for IVC thrombosis are hepatocellular carcinoma, adrenocortical cancer and Wilms tumor, primary leiomyoma or leiomyosarcoma of the IVC.

It is important to characterize the thrombus from RCC for surgical management.

According to TNM classification of RCC, tumor spread into infradiaphragmatic IVC is T3c stage, while extension into the supradiaphragmatic IVC is T4b stage. Also, subclassification into infrahepatic, hepatic and suprahepatic extension can further help the surgeon.

On all imaging, they appear as persistent filling-defects within the IVC. Chronic thrombosis can lead to pericaval and periaortic collateral formation 1.

  • a bland thrombus results from external compression of the IVC by a neoplastic lesion (i.e. no direct invasion), so the IVC is usually narrowed at the site of thrombosis; in contrast, tumor thrombus expands the IVC
  • tumor thrombus will often show continuity with primary tumor
  • in arterial phase, neovascularity may be appreciated in tumor thrombus

Conditions that may mimic thrombus include:

  • pseudothrombosis caused by laminar flow of enhanced blood from renal veins streaming parallel to column of unopacified blood returning from lower body; delayed images will show resolution of filling defect
  • pseudolipoma (paracaval lipoma) is the partial volume artefact due to pericaval fat above caudate lobe, seen commonly in patients with chronic liver disease; coronal reformats usually clear the doubt 2
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Article information

rID: 16688
Synonyms or Alternate Spellings:
  • IVC thrombus
  • Inferior venacava thrombosis
  • Inferior venacava thrombus
  • IVC thrombosis
  • Inferior vena cava thrombosis
  • Thrombosis of the inferior vena cava

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Cases and figures

  • Longitudinal cont...
    Case 1: tumor thrombus CEUS
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  • Case 1: tumor thrombus power Doppler
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  • Case 2
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  •  Case 3
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  • Case 4
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  • Case 5
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  • Case 6: left sided IVC filter with IVC thrombosis
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  • Case 7
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  • Case 8: below filter IVC thrombosis
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