Intestinal angioedema, also known as bowel angioedema, is edema into the submucosal space of the bowel wall following protein extravasation from "leaky" vessels. It can affect both the small and large bowel.
On this page:
Clinical presentation
Patients often present with non-specific findings of abdominal pain, nausea, and vomiting.
Complications
hypovolemic shock: fluid loss into the bowel wall, lumen and peritoneum may be massive 6
Pathology
There are three main types of intestinal angioedema:
hereditary deficiency of C1-inhibitor enzyme
acquired deficiency of C1-inhibitor enzyme (associated with B-cell lymphoproliferative disorders and autoimmune disease)
-
medications
-
angiotensin-converting enzyme inhibitors (ACEi) 3
especially enalapril and lisinopril
angiotensin II receptor blockers
calcium channel blockers 4
-
The exact mechanism of angioedema in the bowel is not completely understood, but it is thought to involve bradykinin pathways and subsequent vasodilation (instead of histamine pathways) during acute periods.
Radiographic features
CT
-
bowel changes
-
long segment concentric thickening of the bowel submucosa
jejunum more often affected
mural stratification
straightening of bowel loops
no obstruction
-
mild mesenteric edema
ascites
no lymphadenopathy
Treatment and prognosis
In cases of medication-induced angioedema, removal of the offending agent usually results in complete resolution.
Differential diagnosis
-
lack of bowel wall enhancement
possible pneumatosis
bowel wall intramural hemorrhage: look for history of anticoagulation
lymphoma: usually more irregular
graft vs host disease: look for history of transplant and immunosuppression