Radiopaedia Courses 25% Discount in response to COVID-19 ends on October 31 EXPLORE OUR COURSES

Intramembranous ossification

Dr Henry Knipe and Dr Pamela Mayhew et al.

Intramembranous ossification describes the process of ossification from mesenchymal cells (stem cells) without a cartilaginous template and is involved in the healing process of fractures. The stages of intramembranous ossification osteogenesis are as follows:

  • mesenchymal cells differentiate into osteoblasts
  • osteoblasts deposit matrix which becomes mineralized
  • immature woven trabeculae (primary spongiosa) is deposited
  • primary spongiosa is replaced by secondary bone
    • bone marrow formation
    • primary cortical bone

Gross anatomy

Seen in the formation of:

Article information

rID: 44008
Section: Anatomy
Tag: refs
Synonyms or Alternate Spellings:

ADVERTISEMENT: Supporters see fewers/no ads

Updating… Please wait.

 Unable to process the form. Check for errors and try again.

 Thank you for updating your details.