Ioflupane (I-123)

Ioflupane (I-123) is a radiopharmaceutical for the diagnosis of Parkinson disease and its differential diagnoses.

  • iodine-123 is a cyclotron product
  • physical half-life is 13.22 hours
  • predominant energy of its gamma spectrum is 159 keV

Ioflupane is the international non-proprietary name of a phenyltropane compound (FPCIT), a cocaine analog. Ioflupane has a high affinity for presynaptic dopamine transporters which are abundant in the striatal region.

I-123 ioflupane is available worldwide and marketed under the trade name DaTSCAN TM.

  • as a cyclotron product, the solution is supplied ready to inject
  • the dose reference activity of I-123 ioflupane is 185 MBq (5 mCi)
  • administration is intravenous
  • thyroid blocking with 120 mg potassium iodide 2 hours before and 24 hours after the injection is recommended
  • SPECT scanning typically is performed 3-6 hours after injection

Reduced putaminal uptake as evidenced visually by the loss of the normal comma- or crescent-shaped uptake in the striatum and the appearance of abnormal period- or oval-shaped uptake in the caudate only is supportive of a diagnosis of a parkinsonian syndrome:

Physics and imaging technology: nuclear medicine
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Article information

rID: 23245
Synonyms or Alternate Spellings:
  • DaTSCAN
  • FP-CIT
  • FPCIT

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