John Cunningham virus
Updates to Article Attributes
John Cunningham (JC) virus is a ubiquitous double-stranded DNA virus of the polyomaviridae family 1. It is the aetiological agent of the progressive multifocal leukoencephalopathy (PML). Cases of cerebellar neuronal involvement (JC virus granule cell neuronopathy) as well as meningitis have also been attributed to this virus in immunosuppressed hosts 4.
Epidemiology
It was reported that ~70% of adults have been exposed to this virus; however, no significant clinical syndrome has been associated with this acquisition in the majority of immunocompetent hosts 1.
History and etymology
The virus was first described by Åström et al. in 1958 2, and was first isolated in 1971 by Padgett et al. The latter group assigned the name of the patient to the virus 3.
-<p><strong>John Cunningham (JC) virus</strong> is a ubiquitous double-stranded DNA virus of the polyomaviridae family <sup>1</sup>. It is the aetiological agent of the <a href="/articles/progressive-multifocal-leukoencephalopathy">progressive multifocal leukoencephalopathy (PML)</a>.</p><h4>Epidemiology</h4><p>It was reported that ~70% of adults have been exposed to this virus; however, no clinical syndrome has been associated with this acquisition <sup>1</sup>. </p><h4>History and etymology </h4><p>The virus was first described by <strong>Åström</strong> et al. in 1958 <sup>2</sup>, and was first isolated in 1971 by <strong>Padgett</strong> et al. The latter group assigned the name of the patient to the virus <sup>3</sup>.</p>- +<p><strong>John Cunningham (JC) virus</strong> is a ubiquitous double-stranded DNA virus of the polyomaviridae family <sup>1</sup>. It is the aetiological agent of the <a href="/articles/progressive-multifocal-leukoencephalopathy">progressive multifocal leukoencephalopathy (PML)</a>. Cases of cerebellar neuronal involvement (JC virus granule cell neuronopathy) as well as meningitis have also been attributed to this virus in immunosuppressed hosts <sup>4</sup>.</p><h4>Epidemiology</h4><p>It was reported that ~70% of adults have been exposed to this virus; however, no significant clinical syndrome has been associated with this acquisition in the majority of immunocompetent hosts <sup>1</sup>. </p><h4>History and etymology </h4><p>The virus was first described by <strong>Åström</strong> et al. in 1958 <sup>2</sup>, and was first isolated in 1971 by <strong>Padgett</strong> et al. The latter group assigned the name of the patient to the virus <sup>3</sup>.</p>
References changed:
- 4. Bag A, Curé J, Chapman P, Roberson G, Shah R. JC Virus Infection of the Brain. AJNR Am J Neuroradiol. 2010;31(9):1564-76. <a href="https://doi.org/10.3174/ajnr.A2035">doi:10.3174/ajnr.A2035</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/20299430">Pubmed</a>
- 4. Bag AK, Curé JK, Chapman PR et-al. JC virus infection of the brain. AJNR Am J Neuroradiol. 2010;31 (9): 1564-76. <a href="http://dx.doi.org/10.3174/ajnr.A2035">doi:10.3174/ajnr.A2035</a> - <a href="http://www.ncbi.nlm.nih.gov/pubmed/20299430">Pubmed citation</a><span class="auto"></span>