John Cunningham virus

John Cunningham virus, but universally called the JC virus, is a ubiquitous double-stranded DNA virus of the polyomaviridae family 1.

It was reported that ~70% of adults have been exposed to this virus; however, no significant clinical syndrome has been associated with this acquisition in the majority of immunocompetent hosts 1

The JC virus is the etiological agent of progressive multifocal leukoencephalopathy (PML). Additionally, rarer manifestations include 4,5:

The virus was first described by Åström et al. in 1958 2, and was first isolated in 1971 by Padgett et al. The latter group assigned the name of the patient to the virus 3.

Infections of the central nervous system
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Article information

rID: 37530
Section: Pathology
Synonyms or Alternate Spellings:
  • JC virus

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