Löfgren syndrome is a specific acute clinical presentation of systemic sarcoidosis that usually manifests with lymphadenopathy, fevers, erythema nodosum, and arthritis.
It is important to not confuse this syndrome with Löffler syndrome, as the names are quite similar but the conditions quite different.
It typically consists of:
- constitutional symptoms
- erythema nodosum
- hilar adenopathy: see thoracic manifestations of sarcoidosis
- arthritis: see musculoskeletal manifestations of sarcoidosis
- uveitis (occasionally)
- parotitis (occasionally)
Treatment and prognosis
Compared to run-of-the-mill sarcoidosis, patients presenting with Löfgren syndrome typically have a better overall prognosis with a self-limited clinical course and spontaneous remission.
History and etymology
It was initially described by Sven Halvar Löfgren (1910-1978), a Swedish physician, in 1952 2.
- 1. Miller BH, Rosado-de-christenson ML, Mcadams HP et-al. Thoracic sarcoidosis: radiologic-pathologic correlation. Radiographics. 1995;15 (2): 421-37. Radiographics (abstract) - Pubmed citation
- 2. Löfgren S, Lundback H. The bilateral hilar lymphoma syndrome; a study of the relation to age and sex in 212 cases. Acta Med Scand. 1952;142 (4): 259-64. - Pubmed citation
Related Radiopaedia articles
- systemic manifestations
- pulmonary and mediastinal manifestations (chest x-ray staging)
- cardiac manifestations
- musculoskeletal manifestations
- head and neck manifestations
- central nervous system manifestations
- abdominal manifestations
- cutaneous manifestations