Lewy bodies

A.Prof Frank Gaillard et al.

Lewy bodies are intracellular cytoplasmic inclusions which result from abnormal alpha-synuclein metabolism (thus diseases with Lewy bodies are synucleinopathies). They also contain other proteins (ubiquitin and alphaB-crystalin), fatty acids, sphingomyelin, and polysaccharides 1,2

Lewy bodies are found in:

  1. Parkinson disease
  2. Lewy body dementia
Neurodegenerative diseases

Neurodegenerative diseases are legion and their classification just as protean. A useful approach is to divide them according to underlying pathological process, although even using this schema, there is much overlap and thus resulting confusion.

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Article information

rID: 13003
Synonyms or Alternate Spellings:
  • Lewy body

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