Löffler syndrome

Simple pulmonary eosinophilia (also known as Löffler syndrome) is a type of pulmonary eosinophilia that typically presents with transient radiographic infiltrates, minimal constitutional upset, and an elevated eosinophil count in peripheral blood.

The cause is not usually identified but a number of allergens have been linked to the syndrome:

  • parasites (e.g. Ascaris spp., Strongyloides spp., Ancylostoma spp.)
  • drugs (e.g. aspirin, penicillin)

There is often a fleeting, non-segmental air space opacification which may be unilateral or bilateral. Usually, has a predominantly peripheral distribution. Pleural effusions and lymphadenopathy are not features.

The condition is usually self-limiting and treated conservatively. Opacities typically resolve within a month 3,5.

A restrictive type cardiomyopathy can develop from endomyocardial fibrosis.

Named after a Swiss physician, Wilhelm Löffler (1887-1972) 2, who first described the case histories of patients with chest radiographic infiltrates in 1932.

General imaging differential considerations include:

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Article information

rID: 7107
System: Chest
Section: Syndromes
Synonyms or Alternate Spellings:
  • Loffler's Syndrome
  • Simple-pulmonary-eosinophila
  • Simple pulmonary eosinophilia
  • Loeffler syndrome

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