Lymphoma (staging)

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~~Hodgkin lymphoma~~Lymphoma staging

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A commonly adopted staging system forHodgkin lymphoma is the Cotswold's modification of the original Ann arbor staging system. Non-Hodgkin lymphoma also uses the same classification ¹. However, contiguous nodal spread is common with Hodgkin lymphoma whereas multifocal nodal involvement and extranodal spread is common with non-Hodgkin lymphoma ¹.

Accurate CT staging has been shown to have a significant impact on treatment and eventual clinical outcome.

stage I: one nodal group: or lymphoid organ (e.g. spleen or thymus)
- stage IE: one ~~extra nodal~~extranodal site
stage II: two or more nodal groups, same side of diaphragm
- stage IIE: ~~one nodal group and one~~localized extranodal site with stage II criteria, both on the same side of the diaphragm
stage III: nodal groups on both sides of the diaphragm
- stage IIIS(1): ~~nodal groups above diaphragm and~~with splenic involvement
- stage IIIE(2): ~~nodal groups above diaphragm and extra nodal~~with localized extranodal site ~~below diaphragm~~
stage IV: ~~one~~ disseminated involvement of one or more extra lymphatic organ (e.g. lung, bone) +/- any nodal involvement

Additional staging variables

X: bulky nodal disease: nodal mass >1/3 of intra thoracic diameter or 10 cm in dimension
A: asymptomatic
B: presence of B symptoms (fever, night sweats and weight loss)

-A commonly adopted staging system for <a href="/articles/hodgkin-lymphoma">Hodgkin lymphoma</a> is the Cotswold's modification of the original Ann arbor staging system. Accurate CT staging has been shown to have a significant impact on treatment and eventual clinical outcome.<ul>
+A commonly adopted staging system for <a href="/articles/hodgkin-lymphoma">Hodgkin lymphoma</a> is the Cotswold's modification of the original Ann arbor staging system. Non-Hodgkin lymphoma also uses the same classification 1. However, contiguous nodal spread is common with Hodgkin lymphoma whereas multifocal nodal involvement and extranodal spread is common with non-Hodgkin lymphoma 1.Accurate CT staging has been shown to have a significant impact on treatment and eventual clinical outcome.<ul>
~~-stage I: one nodal group:<ul><li>~~
~~-stage IE: one extra nodal site</li></ul>~~
+stage I: one nodal group or lymphoid organ (e.g. spleen or thymus)<ul><li>
+stage IE: one extranodal site</li></ul>
~~-stage IIE: one nodal group and one extranodal site, both on the same side of the diaphragm</li></ul>~~
+stage IIE: localized extranodal site with stage II criteria, both on the same side of the diaphragm</li></ul>
~~-stage IIIS(1): nodal groups above diaphragm and splenic involvement</li>~~
+stage IIIS(1): with splenic involvement</li>
~~-stage IIIE(2): nodal groups above diaphragm and extra nodal site below diaphragm</li>~~
+stage IIIE(2): with localized extranodal site</li>
~~-stage IV: one or more extra lymphatic organ (e.g. lung, bone) +/- any nodal involvement</li>~~
+stage IV: disseminated involvement of one or more extra lymphatic organ (e.g. lung, bone) +/- any nodal involvement</li>

References changed:

2. Hopper KD, Diehl LF, Lesar M et-al. Hodgkin disease: clinical utility of CT in initial staging and treatment. Radiology. 1988;169 (1): 17-22. <a href="http://radiology.rsna.org/content/169/1/17.abstract">Radiology (abstract)</a> - <a href="http://www.ncbi.nlm.nih.gov/pubmed/3420256">Pubmed citation</a><div class="ref_v2"></div>
3. Cheson BD, Fisher RI, Barrington SF et-al. Recommendations for Initial Evaluation, Staging, and Response Assessment of Hodgkin and Non-Hodgkin Lymphoma: The Lugano Classification. J. Clin. Oncol. 2014;32 (27): . <a href="http://dx.doi.org/10.1200/JCO.2013.54.8800">doi:10.1200/JCO.2013.54.8800</a> - <a href="http://www.ncbi.nlm.nih.gov/pubmed/25113753">Pubmed citation</a>
1. Cronin CG, Swords R, Truong MT et-al. Clinical utility of PET/CT in lymphoma. AJR Am J Roentgenol. 2010;194 (1): W91-W103. <a href="http://dx.doi.org/10.2214/AJR.09.2637">doi:10.2214/AJR.09.2637</a> - <a href="http://www.ncbi.nlm.nih.gov/pubmed/20028897">Pubmed citation</a>
1. Hopper KD, Diehl LF, Lesar M et-al. Hodgkin disease: clinical utility of CT in initial staging and treatment. Radiology. 1988;169 (1): 17-22. <a href="http://radiology.rsna.org/content/169/1/17.abstract">Radiology (abstract)</a> - <a href="http://www.ncbi.nlm.nih.gov/pubmed/3420256">Pubmed citation</a><div class="ref_v2"></div>

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Lymphoma (staging)

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