There are a number of lymphoma staging systems for both Hodgkin lymphoma and Non-Hodgkin lymphoma including the Ann Arbor classification, Cotswolds-modified Ann Arbor classification, and the Lugano classification.
Cotswolds-modified Ann Arbor classification
Accurate CT staging has been shown to have a significant impact on treatment and eventual clinical outcome.
stage I: one nodal group or lymphoid organ (e.g. spleen or thymus)
- stage IE: one extranodal site
stage II: two or more nodal groups, same side of diaphragm
- stage IIE: localized extranodal site with stage II criteria, both on the same side of the diaphragm
stage III: nodal groups on both sides of the diaphragm
- stage IIIS(1): with splenic involvement
- stage IIIE(2): with localized extranodal site
- stage IIISE: both
- stage IV: disseminated involvement of one or more extralymphatic organ (e.g. lung, bone) +/- any nodal involvement
Additional staging variables:
- A: asymptomatic
- B: presence of B symptoms (fever, night sweats and weight loss)
- X: bulky nodal disease: nodal mass >1/3 of intrathoracic diameter or 10 cm in dimension