Revision 5 for 'Macroamylasemia'

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Macroamylasemia is the presence of serum amylase of a large molecular size, seen in both otherwise healthy individuals, and also in various diseases. Amylase seems to be able to self-polymerize and/or form immune complexes with immunoglobulins.


This condition can be confused with other causes of raised serum amylase (e.g. acute pancreatitis). Macroamylasemia is accompanied by normal serum lipase and urinary amylase levels. Where as in pancreatic disease lipase will usually be elevated as well 2.

Causes of macroamylasemia

  • liver disease
  • diabetes mellitus
  • malignancy
  • malabsorption
  • autoimmune disorders

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