Macromolecular complexes include both macrohormones and macroenzymes, which consist of hormones and enzymes respectively covalently bound to carrier molecules, e.g. immunoglobulins. Their primary importance lies in their ability to produce an artifactually-high level of the particular hormone/enzyme in the blood, e.g. in hyperamylasemia the serum amylase appears to be elevated but may actually be normal.
- macro-thyroid stimulating hormone (macro-TSH)