Manganism is the clinical syndrome resulting from acute or chronic overexposure to the transition metal manganese. It primarily manifests as parkinsonism and is frequently clinically, radiologically and histopathologically indistinguishable from classic idiopathic Parkinson disease 1.
- typical parkinsonism
- rest tremor
- postural instability
Manganese is an essential trace element with a vital role in the synthesis of several key enzymes, vitamin B complex and vitamin C, as well as several other substrates. However certain occupations, especially welders, can be exposed to toxic levels of the element.
- T1: hyperintense signal in the globus pallidi bilaterally
- T2: normal signal in the globus pallidi
The degree of T1 hyperintensity can be quantified as the pallidal index (PI). The pallidal index approximately correlates to the lifetime exposure and level of serum manganese 2.