Mantle cell lymphoma

Dr Henry Knipe and Dr Yuranga Weerakkody et al.

Mantle cell lymphoma (MCL) is a type of non-Hodgkin lymphoma (NHL) and accounts for ~5% of all NHL. It is a malignant neoplasm of virgin B cells that closely resemble normal mantle zone B cells surrounding germinal centers.

They occur in older adults (mean age ~60 years). There is a recognized male predilection (M:F of ~4:1) 2.

MCL is usually widespread at diagnosis and frequently involves, apart from lymph nodes, the spleen, bone marrow, and gastrointestinal tract.

MCL is characterized by an infiltrate of small to medium-sized cells with folded nuclei and scant cytoplasm. The diagnosis of MCL is confirmed by histological assessment and immunohistochemical evaluation, including cyclin D1.

Many cases have the t(11;14)(q13;q32) translocation that causes overexpression of cyclin-D1 2.

Survival is short with a ~50% 5-year survival. Over one-third of the patients can die within a year despite the administration of aggressive combination chemotherapy.

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Article information

rID: 11065
Synonyms or Alternate Spellings:
  • Lymphoma - mantle cell
  • Mantle cell lymphoma (MCL)

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Cases and figures

  • Case 1: showing para-aortic involvement
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  • Case 2: nodal and gastrointestinal
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