Mesothelioma, also known as malignant mesothelioma, is an aggressive malignant tumor of the mesothelium. Most tumors arise from the pleura, and so this article will focus on pleural mesothelioma.
Given the presence of the mesothelium in different parts of the body, mesothelioma can arise in various locations 17:
- pleural mesothelioma (~90%)
- peritoneal mesothelioma (~10%)
- pericardial mesothelioma (<1%)
- cystic/multicystic mesothelioma
- tunica vaginalis testis mesothelioma (<1%)
Mesothelioma is an uncommon entity and accounts for 5-28% of all malignancies that involve the pleura 1,7. There is a strong association with exposure to asbestos fibers (~10% risk during lifetime; 40-80% of patients have a history of asbestos exposure). Unlike other asbestos-related lung diseases, it does not appear to be dose-dependent 1.
Not all types of asbestos are strongly implicated, with crocidolite being the main causative fiber type. Not surprisingly, given the sources of asbestos exposure being predominantly mining, construction, lagging and machinery mechanics, 60-80% of cases are encountered in males, in general, 20 to 35 years after exposure 1,5,6. Some areas of the world have very regional hotspots, such as Belfast in Northern Ireland, due to the historic shipbuilding industry.
There is also increased risk for those with household exposure (e.g. family of exposed workers) 14.
There has been no convincing evidence for an association with smoking 6.
Typically patients present with dyspnea and low back non-pleuritic chest pain. Pleural effusions are seen in the vast majority of patients at some stage during their disease. Up to 25% of patients have metastatic disease at the time of presentation if staged with FDG PET 5.
Typically mesothelioma is thought of as a locally-aggressive disease, however distant extranodal metastases are seen 15, albeit uncommonly. In a postmortem study of 318 patients, 55% patients were found to have extrathoracic metastases, the commonest sites being the liver (32%), spleen (11%), thyroid (7%) and brain (3%) 16. Of course prevalence of metastases on imaging is likely to be lower than on postmortem studies.
- asbestos-fiber exposure: causes majority of cases
- erionite-fiber exposure: naturally occurring mineral used in building, particularly in Turkey 12
- simian virus 40 (SV40) 13
- radiation exposure 13
There are three histological types of mesothelioma:
- epithelial: ~60%
- mixed: 25%
- sarcomatoid: 15%
The cytological and histological diagnosis can be difficult, with mesothelial hyperplasia and metastatic adenocarcinoma appearing similar. Specific markers are helpful including:
- epithelial membrane antigen
- mesothelin (elevated in 84% of malignant mesothelioma versus <2% with other pleural diseases 6)
Subtypes such as multicystic/cystic mesothelioma are rarer and less aggressive.
Chest radiographs are non-specific and of limited utility 6. The following features may be evident:
- pleural opacity which may extend around and encase the lung
- reduced volume of the affected hemithorax, resulting in ipsilateral shift of the mediastinum (common) 4
- rib destruction or extension beyond the lateral and anterior margins of the chest wall
- +/- mediastinal lymphadenopathy
- +/- pleural effusion
CT is most commonly used for imaging assessment of mesothelioma, and sufficient for accurate staging of disease in most patients.
- pleural mass or nodular thickening of soft tissue attenuation
- tends to cause "inward" contraction of the hemithorax, e.g. ipsilateral mediastinal shift
- pattern of spread
- pattern of spread initially to adjacent pleura
- involvement pleural fissures
- eventually grows toward lung encasement ("pleural rind')
- predilection for local invasion
- involvement of chest wall, diaphragm, and mediastinal content typical 1,2,4
- chest wall involvement
- infiltration of the extrapleural fat plane 4
- obvious direct extension in bone or muscle 4
- known to invade along prior catheter and biopsy tracks 18
- pericardial effusion may suggest transpericardial extension 3,4
- frequent metastasis to local lymph nodes and contralateral lung
- pattern of spread initially to adjacent pleura
- seen in 20% - usually represents engulfment of calcified pleural plaques rather than true tumor calcification 4
- sarcomatoid variants may contain calcific osteosarcoma or chondrosarcomatous components
MRI, although not routinely used, may have a role in refining the staging and better delineating the extent of the disease in surgical candidates especially concerning the chest wall and diaphragmatic invasion 4.
- T1: iso to slightly hyperintense c.f muscle 4,6
- T2: iso to hyperintense c.f muscle 4,6
- C+ (Gd): enhancement usually present
Positron emission tomography is becoming useful in two clinical settings 4:
- differentiating between benign and malignant asbestos-related pleural thickening
- assessing for nodal metastases
In addition, there appears to be a correlation between the degree of FDG uptake and the biological aggressiveness of the tumor, which may help to guide treatment 4.
Treatment and prognosis
Treatment continues to be challenging and the long-term survival is poor. Single modality treatment (surgery, radiotherapy, chemotherapy, immunotherapy and even photodynamic therapy) have not been shown to improve survival 3. More recently multi-modality treatment has had some impact on favourable subgroups (early disease, and epithelioid histology). Treatment includes:
- extrapleural pneumonectomy
- adjuvant chemotherapy
The prognosis is poor for all tumor types with a median overall survival without treatment of 4-12 months 3. In favourable patient subgroups up to 45% 5-year survival may be achievable 3, however even with aggressive multi-modality therapy overall 5-year survival remains poor (3-18%) 3 with a median survival time of approximately 18 months 4.
The differential is dependent on the exact nature of tumor involvement and the modality. General imaging differential considerations include
- pleural effusion (especially if loculated): on radiographs
- pleural metastases (especially with pleural carcinomatosis)
- peripheral bronchogenic carcinoma
- solitary fibrous tumor of pleura
- other pleural based tumors
- tumor like conditions of the pleura
- avoid the temptation of performing an image-guided biopsy, as mesothelioma is notorious for aggressively seeding along the biopsy track
- 1. Naidich DP, Srichai MB, Krinsky GA. Computed tomography and magnetic resonance of the thorax. Lippincott Williams & Wilkins. (2007) ISBN:0781757657. Read it at Google Books - Find it at Amazon
- 2. Pineda V, Andreu J, Cáceres J et-al. Lesions of the cardiophrenic space: findings at cross-sectional imaging. Radiographics. 27 (1): 19-32. doi:10.1148/rg.271065089 - Pubmed citation
- 3. Zielinski M, Hauer J, Hauer L et-al. Staging algorithm for diffuse malignant pleural mesothelioma. Interact Cardiovasc Thorac Surg. 2010;10 (2): 185-9. doi:10.1510/icvts.2009.213611 - Pubmed citation
- 4. Wang ZJ, Reddy GP, Gotway MB et-al. Malignant pleural mesothelioma: evaluation with CT, MR imaging, and PET. Radiographics. 24 (1): 105-19. doi:10.1148/rg.241035058 - Pubmed citation
- 5. DeVita VT, Lawrence TS, Rosenberg SA et-al. DeVita, Hellman, and Rosenberg's cancer, principles & practice of oncology. Lippincott Williams & Wilkins. (2008) ISBN:0781772079. Read it at Google Books - Find it at Amazon
- 6. Tyszko SM, Marano GD, Tallaksen RJ et-al. Best cases from the AFIP: Malignant mesothelioma. Radiographics. 27 (1): 259-64. doi:10.1148/rg.271065105 - Pubmed citation
- 7. Leung AN, Müller NL, Miller RR. CT in differential diagnosis of diffuse pleural disease. AJR Am J Roentgenol. 1990;154 (3): 487-92. AJR Am J Roentgenol (abstract) - Pubmed citation
- 8. Wong WL, Johns TA, Herlihy WG et-al. Best cases from the AFIP: multicystic mesothelioma. Radiographics. 24 (1): 247-50. doi:10.1148/rg.241035068 - Pubmed citation
- 9. Koo PJ, Wills JS. Case 146: Benign multicystic mesothelioma. Radiology. 2009;251 (3): 944-6. doi:10.1148/radiol.2513071235 - Pubmed citation
- 10. Wang ZJ, Reddy GP, Gotway MB et-al. CT and MR imaging of pericardial disease. Radiographics. 2003;23 Spec No (suppl 1): S167-80. doi:10.1148/rg.23si035504 - Pubmed citation
- 11. Bridda A, Padoan I, Mencarelli R et-al. Peritoneal mesothelioma: a review. MedGenMed. 2007;9 (2): 32. Free text at pubmed - Pubmed citation
- 12. Demirer E, Ghattas CF, Radwan MO et-al. Clinical and prognostic features of erionite-induced malignant mesothelioma. Yonsei Med. J. 2015;56 (2): 311-23. doi:10.3349/ymj.2015.56.2.311 - Free text at pubmed - Pubmed citation
- 13. Qi F, Carbone M, Yang H et-al. Simian virus 40 transformation, malignant mesothelioma and brain tumors. Expert Rev Respir Med. 2011;5 (5): 683-97. doi:10.1586/ers.11.51 - Free text at pubmed - Pubmed citation
- 14. Ferrante D, Bertolotti M, Todesco A et-al. Cancer mortality and incidence of mesothelioma in a cohort of wives of asbestos workers in Casale Monferrato, Italy. Environ. Health Perspect. 2007;115 (10): 1401-5. doi:10.1289/ehp.10195 - Free text at pubmed - Pubmed citation
- 15. Tertemiz KC, Ozgen Alpaydin A, Gurel D, Savas R, Gulcu A, Akkoclu A. Multiple distant metastases in a case of malignant pleural mesothelioma. (2014) Respiratory medicine case reports. 13: 16-8. doi:10.1016/j.rmcr.2014.07.003 - Pubmed
- 16. Finn RS, Brims FJH, Gandhi A, Olsen N, Musk AW, Maskell NA, Lee YCG. Postmortem findings of malignant pleural mesothelioma: a two-center study of 318 patients. (2012) Chest. 142 (5): 1267-1273. doi:10.1378/chest.11-3204 - Pubmed
- 17. Enewold L, Sharon E, Thomas A. Patterns of care and survival among patients with malignant mesothelioma in the United States. (2017) Lung cancer (Amsterdam, Netherlands). 112: 102-108. doi:10.1016/j.lungcan.2017.08.009 - Pubmed
- 18. Miller BH, Rosado-de-Christenson ML, Mason AC, Fleming MV, White CC, Krasna MJ. From the archives of the AFIP. Malignant pleural mesothelioma: radiologic-pathologic correlation. (1996) Radiographics : a review publication of the Radiological Society of North America, Inc. 16 (3): 613-44. doi:10.1148/radiographics.16.3.8897628 - Pubmed