Multiple endocrine neoplasia type IV

Last revised by Harry Yip on 8 Mar 2024

Citation, DOI, disclosures and article data

Citation:

Knipe H, Yip H, Bell D, et al. Multiple endocrine neoplasia type IV. Reference article, Radiopaedia.org (Accessed on 18 Apr 2024) https://doi.org/10.53347/rID-56653

DOI:

https://doi.org/10.53347/rID-56653

Permalink:

https://radiopaedia.org/articles/56653

rID:

56653

Article created:

14 Nov 2017, Henry Knipe ◉ ◈

Disclosures:

At the time the article was created Henry Knipe had no recorded disclosures.

View Henry Knipe's current disclosures

Last revised:

8 Mar 2024, Harry Yip

Disclosures:

At the time the article was last revised Harry Yip had no financial relationships to ineligible companies to disclose.

View Harry Yip's current disclosures

Revisions:

4 times, by 4 contributors - see full revision history and disclosures

Systems:

Head & Neck

Tags:

stub, refs, cases, endocrine

Synonyms:

Multiple endocrine neoplasia type IV (MEN4)
MENX
MEN4
MEN type 4
MEN type IV

Multiple endocrine neoplasia type IV (MEN4), previously known as MENX, is a rare type of MEN with clinical overlap with MEN1 but is due to a CDKN1B mutation. It is characterized by ^1,2:

parathyroid adenoma
- primary hyperparathyroidism in 80%
anterior pituitary adenoma
neuroendocrine tumors (pulmonary, gastrointestinal, pancreatic)
associated with other tumors of the reproductive tract, adrenal glands and kidneys