Multiple myeloma is a monoclonal gammopathy and is the most common primary malignant bone neoplasm in adults. It arises from red marrow due to monoclonal proliferation of plasma cells and manifests in a wide range of radiographic abnormalities. Multiple myeloma remains incurable.
Four main patterns are recognized:
- disseminated form: multiple well-defined "punched out" lytic lesions: predominantly affecting the axial skeleton
- disseminated form: diffuse skeletal osteopenia
- solitary plasmacytoma: a single large/expansile lesion most commonly in a vertebral body or in the pelvis
- osteosclerosing myeloma
The remainder of this article relates to the disseminated forms. Please refer to the article plasmacytoma for discussion of the latter.
Smouldering multiple myeloma refers to a form that falls on the spectrum between monoclonal gammopathy of unknown significance (MGUS) and active multiple myeloma. Patients are asymptomatic, with worse biochemistry than MGUS but without the end-organ damage of active multiple myeloma 9.
Multiple myeloma is a common malignancy in patients above 40 (70% of cases are diagnosed between ages 50 and 70 with a median age of diagnosis being 69 years) with a male predilection (M:F 2:1) 7,12. It accounts for 1% of all malignancies and 10% of all hematological disease 12. Multiple myeloma and osteosarcoma combined account for approximately 50% of all primary bone malignancies 7.
Clinical presentation of patients with multiple myeloma is varied, and includes 1,2,7:
- bone pain
- initially intermittent, but becomes constant
- worse with activity/weight-bearing, and thus is worse during the day
- typically normochromic/normocytic
- renal failure
The typical features can be recalled with the mnemonic CRAB 12.
Presentation may also be with a complication, including:
- vertebral compression fracture
- long bone fracture (e.g. proximal femur)
- recurrent infection: e.g. pneumonia due to leukopenia
- plasmacytomas typically progress to multiple myeloma
The initial presentation occasionally is a polyneuropathy when it is part of a POEMS syndrome (mostly the sclerotic form).
Laboratory findings include:
- reverse albumin/globulin ratio (i.e. low albumin, high globulin)
- monoclonal gammopathy (IgA and/or IgG peak)
- Bence Jones protein (Ig light chain) proteinuria
- decreased or normal ALP unless there is a pathological fracture due to impaired osteoblastic function
The most popular staging system, the International Staging System, uses the combination of β2-microglobulin test and serum albumin 6.
Approximately 1% of cases will have negative serum electrophoresis and negative urine Bence Jones protein.
Multiple myeloma results from monoclonal proliferation of malignant plasma cells which produce immunoglobulins (commonly IgG) and infiltrate haemopoietic locations (i.e. red marrow).
Renal involvement is common and renal failure is multifactorial:
- obstructive casts form in the renal tubules composed of Bence Jones proteins, immunoglobulins, albumin and Tamm-Horsfall proteins
- most common cause of renal failure in multiple myeloma
- direct nephrotoxicity of Bence Jones proteins on the epithelial cells of the renal tubules
- hypercalcemia and dehydration
- hyperuricemia and urate nephropathy due to high cell turnover
- amyloidosis (AL type)
- increased risk of renal infection
Distribution of multiple myeloma mirrors that of red marrow in the older individual, and thus this is mostly encountered in the axial skeleton and proximal appendicular skeleton:
- vertebrae (most common)
- shoulder girdle
- long bones
- extraskeletal structures (extraosseous myeloma): rare
Radiology has a number of roles in the diagnosis and management for multiple myeloma:
- suggest the diagnosis / exclude other causes
- assess possible mechanical complications (e.g. pathological fracture)
- assess disease progression
Disseminated multiple myeloma has two common radiological appearances, although it should be noted that initially, radiographs may be normal, despite the presence of symptoms. The two main diffuse patterns are 12:
- numerous, well-circumscribed, lytic bone lesions (more common)
- generalized osteopenia (less common)
A skeletal survey is essential not only for the diagnosis of multiple myeloma but also in pre-empting potential complications (e.g. pathological fracture) and assessing response to therapy. ~40% bone destruction is required for lesion detection, thus giving the skeletal survey a high false-negative rate of ~50% (range 30-70%) 12.
The vast majority of lesions are purely lytic, sharply defined/punched out, with endosteal scalloping when abutting the cortex. Lesions are sclerotic in only 3% of patients 7.
Whole-body low dose (WBLD) CT is more accurate than a skeletal survey with a sensitivity of ~70% and specificity of ~90% with a dose 1-2x that of a skeletal survey 12. WBLD CT is also better to assess the risk of pathological fracture in severely affected bones as well as the presence of extramedullary lesions 12.
MRI is more sensitive in detecting multiple lesions compared to the standard plain film skeletal survey and CT 8,12. Five patterns have been described 12:
- normal bone marrow signal
- diffuse involvement
- focal involvement
- combined diffuse and focal involvement
- variegated ("salt and pepper")
MRI signal characteristics
Most frequently used MR sequences for the evaluation of bone marrow are conventional T1 spin-echo and T2 spin-echo sequences 11.
- typically low signal
- high-grade, diffuse involvement may become isointense to adjacent normal marrow
T2 with fat-suppression
- high signal
- infiltration of the ribs is probably best appreciated on T2 images with fat suppression, appearing bright: ‘white ribs sign’
T1 C+ (Gd)
- several enhancement curves may be seen.
- type 4 curve:
- represents a steep wash-in of contrast medium, due to the high vascularization and perfusion with leakage through the highly permeable capillaries, followed by an early wash-out back into the intravascular space because of the small interstitial space with closely packed plasma cells 10-11
- type 3 and type 5 curves may also be seen.
- type 4 curve:
- DWI/ADC: lesions can appear as areas of increased diffusivity compared to the very low diffusion of normal background marrow 11
Bone scintigraphy appearance of patients with disseminated multiple myeloma is variable due to the potential lack of osteoblastic activity. Larger lesions may be either hyperactive (hot) or photopenic (cold). Bone scans may also be normal. Therefore, bone scans usually do not contribute significant information to the workup of patients with suspected or established disseminated multiple myeloma, as the sensitivity of detecting lesions is less than that of a plain film skeletal survey 7.
PET-CT has had a growing role in the management of this disease, as it is effective in identifying the distribution of disease. 18F-FDG uptake by the myeloma lesions corresponds to areas of bone lysis seen on CT.
Treatment and prognosis
Currently, multiple myeloma remains incurable, although the introduction of thalidomide, lenalidomide and bortezomib (proteasome inhibitor) have provided significant survival gains 6. These are typically used in combination with older agents such as cyclophosphamide, melphalan, prednisolone and doxorubicin 6.
Treatment response is usually assessed by measuring serum markers and bone marrow sampling.
Stem-cell harvest and autologous stem cell transplant post-chemotherapeutic/radiotherapy bone marrow ablation are also used, although relapse is inevitable.
The main differential is that of widespread bony metastases. Findings that favor the diagnosis of bone metastases over that of multiple myeloma include:
- more commonly affect the vertebral pedicles rather than vertebral bodies
- rarely involve mandible, distal axial skeleton
- although both entities have variable bone scan appearances (both hot and cold) unlike myeloma, extensive bony metastases rarely have a normal appearance
Other rare entities include:
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- 9. Dispenzieri A, Stewart AK, Chanan-Khan A et-al. Smoldering multiple myeloma requiring treatment: time for a new definition?. Blood. 2013;122 (26): 4172-81. doi:10.1182/blood-2013-08-520890 - Free text at pubmed - Pubmed citation
- 10. Baur-Melnyk A, Buhmann S, Durr HR, Reiser M. Role of MRI for the diagnosis and prognosis of multiple myeloma. Eur J Radiol. 2005;55:56–63. Pubmed citation
- 11. Dutoit JC, Verstraete KL. MRI in multiple myeloma: a pictorial review of diagnostic and post-treatment findings. (2016) Insights into imaging. 7 (4): 553-69. doi:10.1007/s13244-016-0492-7 - Pubmed
- 12. Alípio G. Ormond Filho, Bruno C. Carneiro, Daniel Pastore, Igor P. Silva, Sâmia R. Yamashita, Flávio D. Consolo, Vânia T. M. Hungria, Alex F. Sandes, Edgar G. Rizzatti, Marcelo A. C. Nico. Whole-Body Imaging of Multiple Myeloma: Diagnostic Criteria. (2019) RadioGraphics. 39 (4): 1077-1097. doi:10.1148/rg.2019180096 - Pubmed
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