Nothnagel syndrome

Nothnagel syndrome is a rare midbrain stroke syndrome that involves the tectum of the midbrain, including the quadrigeminal plate 1-4.

Classically, the syndrome involves the oculomotor nerve fascicles and superior cerebellar peduncle, leading to ipsilateral CN III palsy and limb ataxia respectively 1-4.

Although it can be caused by stroke, especially hemorrhages rather than infarctions, it is more commonly seen due to neoplasm 1-4.

Lesions are in the tectum of the midbrain with imaging characteristics depending on underlying cause.

The syndrome was first described by Hermann Nothnagel (1841-1905), a German-Austrian physician, in 1879 5.

Stroke and intracranial haemorrhage
Share article

Article information

rID: 54279
Section: Syndromes
Synonyms or Alternate Spellings:
  • Nothnagel's syndrome

Support Radiopaedia and see fewer ads

Updating… Please wait.

 Unable to process the form. Check for errors and try again.

 Thank you for updating your details.