Ovarian choriocarcinoma

An ovarian choriocarcinoma is a rare sub type of ovarian germ cell tumor.

They account for less than 1% of ovarian tumors. 

In pre-menarchal patients, the tumors manifest with iso-sexual precocity (approximately 50% of cases) and other symptoms associated with excessive hormone production.

A choriocarcinoma arising in association with the ovary can occur in a number of situations. The tumors may occur during or outside of pregnancy. 

A gestational ovarian choriocarcinoma may represent a metastasis from a uterine choriocarcinoma or much rarely arise from an ovarian ectopic pregnancy 1.

Primary ovarian choriocarcinoma (non gestational ovarian choriocarcinoma) arises presumably from a germ cell and is extremely rare. These may be mixed with other germ cell tumors like immature teratoma, dysgerminoma or rarely occur in a pure form - pure primary choriocarcinoma of the ovary

The tumors are formed from placental trophoblastic elements. While most gestational choriocarcinomas show haematogenous spread, the non gestational choriocarcinoma tend to follow the lymphatic system.

Serum β-HCG levels are often elevated

On imaging, choriocarcinomas appear as vascular solid tumors with cystic, hemorrhagic, and necrotic areas. 

The staging depend on the original site of the tumor

As with choriocarcinoma in general, the tumors are capable of widespread metastases.  

Choriocarcinoma is however extremely sensitive to chemotherapy, which is the mainstay of treatment. Since the disease is associated with a high incidence of metastasis and recurrence, the recommended management of primary extrauterine choriocarcinoma is often complete surgical resection followed by chemotherapy

Germ cell tumours
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Article information

rID: 15180
System: Gynaecology
Tag: cases
Synonyms or Alternate Spellings:
  • Choriocarcinoma of the ovary
  • Choriocarcinoma of ovary
  • Choriocarcinoma of the ovaries
  • Choriocarcinoma of ovaries

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Cases and figures

  • Case 1: with cerebral and pulmonary metastases
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