Citation, DOI, disclosures and article data
Citation:
Weerakkody Y, Knipe H, Thibodeau R, et al. Paclitaxel lung toxicity. Reference article, Radiopaedia.org (Accessed on 19 Apr 2024) https://doi.org/10.53347/rID-84862
Disclosures:
At the time the article was last revised Henry Knipe had the following disclosures:
- Integral Diagnostics, Shareholder (ongoing)
- Micro-X Ltd, Shareholder (ongoing)
These were assessed during peer review and were determined to
not be relevant to the changes that were made.
View Henry Knipe's current disclosures
Paclitaxel lung toxicity is a form of drug-induced lung disease that can precipitate following the use of paclitaxel which is a chemotherapeutic agent commonly used in the treatment of breast, ovarian, and non-small cell lung cancers. Nab-paclitaxel can also be bound to human serum albumin forming nab-paclitaxel to reduce hypersensitivity reactions 5.
Pathology
Various types of paclitaxel/nab-paclitaxel lung injuries have been described:
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hypersensitivity reactions 1
thought to occur in around ~15% (range 3-30%) of treated patients
most frequently manifest as dyspnea, bronchospasm, urticaria, hypotension, and erythematous rashes
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acute bilateral pneumonitis 2
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nab-paclitaxel induced lung injury 5
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1. Wong P, Leung A, Berry G et al. Paclitaxel-Induced Hypersensitivity Pneumonitis. AJR Am J Roentgenol. 2001;176(3):718-20. doi:10.2214/ajr.176.3.1760718 - Pubmed
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2. Khan A, McNally D, Tutschka P, Bilgrami S. Paclitaxel-Induced Acute Bilateral Pneumonitis. Ann Pharmacother. 1997;31(12):1471-4. doi:10.1177/106002809703101205 - Pubmed
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3. Torrisi J, Schwartz L, Gollub M, Ginsberg M, Bosl G, Hricak H. CT Findings of Chemotherapy-Induced Toxicity: What Radiologists Need to Know About the Clinical and Radiologic Manifestations of Chemotherapy Toxicity. Radiology. 2011;258(1):41-56. doi:10.1148/radiol.10092129 - Pubmed
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4. Bielopolski D, Evron E, Moreh-Rahav O, Landes M, Stemmer S, Salamon F. Paclitaxel-Induced Pneumonitis in Patients with Breast Cancer: Case Series and Review of the Literature. J Chemother. 2017;29(2):113-7. doi:10.1179/1973947815Y.0000000029 - Pubmed
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5. Yoshioka K, Abe M, Shiko Y et al. Clinical Characteristics and Risk Factors of Lung Injury Induced by Nab-Paclitaxel. Drug Des Devel Ther. 2022;16:759-67. doi:10.2147/DDDT.S342283 - Pubmed
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