Pancreatic lipomatosis

Pancreatic lipomatosis refers to the fatty replacement of pancreatic parenchyma. This finding is most often associated with obesity and aging. 

It tends to be the commonest pathological condition involving the pancreas. The condition may occasionally simulate a mass-like lesion particularly when fatty replacement is uneven 1

Pathology

Subtypes
  • even pancreatic lipomatosis
  • uneven pancreatic lipomatosis 3
    • type 1a: preferential fatty replacement of the head
    • type 1b: preferential fatty replacement of head, neck and body
    • type 2a: preferential fatty replacement of head and uncinate process
    • type 2b: fatty replacement of most of the pancreas except the peribiliary region
Etiology
Systemic
Local
Syndromic associations

Differential diagnosis

Imaging differential considerations include:

Pancreatic pathology
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Article information

rID: 8600
Synonyms or Alternate Spellings:
  • Fatty infiltration of pancreas
  • Lipomatosis of pancreas
  • Lipomatosis of the pancreas
  • Fatty replacement of the pancreas
  • Pancreatic steatosis
  • Steatotic pancreas
  • Steatosis of the pancreas

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Cases and figures

  • Figure 1: causes of pancreatic lipomatosis
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  • Case 1: T2
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  • Case 1: T1 out-of-phase
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  • Case 1: T1 in-phase
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  • Case 2: T1 out-of-phase
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  • Case 2: T1 in-phase
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  • Case 3: total pancreatic lipomatosis in cystic fibrosis
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  • Case 4: presumably result of aging
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  • Case 5: Shwachman Diamond syndrome
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  • Case 6: pancreatic lipomatosis
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