Serous carcinoma of the endometrium

Last revised by Joshua Yap on 12 Aug 2022

Serous carcinoma of the endometrium is an uncommon histological subtype of endometrial carcinoma accounting for only 5-10% of all such tumors 2. It is has a clinically aggressive form with early extension of the tumor via fallopian tubes into the peritoneum and peritoneal seeding. This accounts for its poorer prognosis compared to the other adenocarcinomas of the uterus. This is thought to closely resemble ovarian serous carcinoma 1.

Pathology

Like is ovarian counterpart, it is characterized by glandular growth patterns and/or papillary projections, and frequently contains psammoma bodies (may be found in a third of cases) that may calcify 2

Markers

This subtype may increase serum CA-125 levels 2.

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