Pineal parenchymal tumor of intermediate differentiation
Updates to Article Attributes
Pineal parenchymal tumourtumours with intermediate differentiation (PPTID) are, as the name suggests, tumours which fall between pineocytoma (well differentiated, WHO grade I) and pineoblastomas (poorly differentiated, WHO grade IV) and are considered WHO grade II / III tumours2. This is tumour of middle age adults with male and females are affected equally.
Their pathology, radiographic appearance and biological behaviour are also intermediate. They may invade adjacent structures and also spread along CSF (imaging of the intire craniospinal axis is required 3).
Pathologically they do not demonstrate the highly differentiated appearance of pineocytomas, but also lack the malignant small blue cell appearance of a pineoblastoma.
-<p><strong>Pineal parenchymal tumour with intermediate differentiation</strong> are, as the name suggests tumours which fall between <a href="/articles/pineocytoma">pineocytoma</a> (well differentiated, WHO grade I) and <a href="/articles/pineoblastoma">pineoblastomas</a> (poorly differentiated, WHO grade IV) and are considered WHO grade II / III tumours <sup>2</sup>. This is tumour of middle age adults with male and females are affected equally. </p><p>Their pathology, radiographic appearance and biological behaviour are also intermediate. They may invade adjacent structures and also spread along CSF.</p><p>Pathologically they do not demonstrate the highly differentiated appearance of pineocytomas, but also lack the malignant small blue cell appearance of a pineoblastoma. </p>- +<p><strong>Pineal parenchymal tumours with intermediate differentiation (PPTID)</strong> are, as the name suggests, tumours which fall between <a href="/articles/pineocytoma">pineocytoma</a> (well differentiated, <a title="WHO classification of CNS tumours" href="/articles/cns-tumours-classification-and-grading-who">WHO</a> grade I) and <a href="/articles/pineoblastoma">pineoblastomas</a> (poorly differentiated, WHO grade IV) and are considered WHO grade II / III tumours <sup>2</sup>. This is tumour of middle age adults with male and females are affected equally. </p><p>Their pathology, radiographic appearance and biological behaviour are also intermediate. They may invade adjacent structures and also spread along CSF (imaging of the intire craniospinal axis is required <sup>3</sup>).</p><p>Pathologically they do not demonstrate the highly differentiated appearance of pineocytomas, but also lack the malignant small blue cell appearance of a pineoblastoma. </p>
References changed:
- 3. Smith AB, Rushing EJ, Smirniotopoulos JG. From the archives of the AFIP: lesions of the pineal region: radiologic-pathologic correlation. Radiographics. 2010;30 (7): 2001-20. <a href="http://radiographics.rsna.org/content/30/7/2001.full">Radiographics (full text)</a> - <a href="http://dx.doi.org/10.1148/rg.307105131">doi:10.1148/rg.307105131</a> - <a href="http://www.ncbi.nlm.nih.gov/pubmed/21057132">Pubmed citation</a><span class="ref_v3"></span>
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