Revision 2 for 'Preinvasive adenocarcinoma lesion of the lung'

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Preinvasive adenocarcinoma lesion of the lung

Preinvasive lesions for lung adenocarcinoma are a type of small noninvasive lung lesion which are closely related to adenocarcinoma of the lung. They may represent a spectrum of premalignant and low-grade malignant lesions.

The category includes two types of lesions:


In 2011, the International Association for the Study of Lung Cancer (IASLC), American Thoracic Society (ATS), and European Respiratory Society (ERS) introduced a new classification and terminology for adenocarcinoma of the lung.  In addition to retiring the term "bronchoalveolar carcinoma (BAC)", the 2011 update officially recognized "adenocarinoma in situ" as a distinct entity with excellent clinical prognosis. 

Given its relatively recent recognition, adenocarcinoma in situ remains somewhat controversial and is variable regarded as a low-grade malignancy.


Atypical adenomatous hyperplasia and adenocarcinoma in situ may be considered a spectrum of premalignant disease, where atypical adenomatous hyperplasia is typically a small (<5 mm) lesion with mild-moderate cellular atypia, while adenocarcinoma in situ lesions are larger, but still ≤3 cm and without evidence of invasion. Indeed, intermediate cases may be difficult to distinguish 1.

Findings which indicate more advanced genetic alteration, such as non-lepidic (e.g. papillary) growth patterns or tumor necrosis, indicate a higher

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