POL accounts for ~1.5% of ovarian tumors 5.
The rarity of this condition is probably contributed by lack of lymphoid tissue in the ovary 4-5. In almost all of cases instances, it tends to be non-Hodgkin lymphoma (~0.5% of NHL tends to involve the ovary 5) with diffuse large B-cell lymphoma (DLBCL) being a dominant histological type 2. Burkitt lymphoma has also been infrequently described.
Imaging features are usually non-specific on ultrasound.
Once the diagnosis is made CT is the preferred imaging modality of ongoing assessment particularly for staging purposes. Often tends to be hypoattenuating on CT with mild enhancement post contrast 4.
Tends to be of a relatively homogenous signal. Described signal characteristics include 4:
- T1: hypointense
- T2: slightly hyperintense
This is one of the rare situations where the FIGO staging system is not used. Instead, the standard non-Hodgkin lymphoma staging system is used.
Treatment and prognosis
The prognosis generally tends to be better than for other primary tumors of the ovary.
- 1. Kapetanakis V, Karlin NJ, Mccullough AE et-al. Primary ovarian malignant lymphoma presenting as ovarian carcinomatosis: a case report and literature review. Eur. J. Gynaecol. Oncol. 2010;31 (6): 701-2. - Pubmed citation
- 2. Zhao XY, Hong XN, Cao JN et-al. Clinical features and treatment outcomes of 14 cases of primary ovarian non-Hodgkin's lymphoma: a single-center experience. Med. Oncol. 2010;doi:10.1007/s12032-010-9578-0 - Pubmed citation
- 3. Dao AH. Malignant lymphoma of the ovary: report of a case successfully managed with surgery and chemotherapy. Gynecol. Oncol. 1998;70 (1): 137-40. doi:10.1006/gyno.1998.5033 - Pubmed citation
- 4. Crasta JA, Vallikad E. Ovarian lymphoma. Indian J Med Paediatr Oncol. 2009;30 (1): 28-30. doi:10.4103/0971-5851.56333 - Free text at pubmed - Pubmed citation
- 5. Crawshaw J, Sohaib SA, Wotherspoon A et-al. Primary non-Hodgkin's lymphoma of the ovaries: imaging findings. Br J Radiol. 2007;80 (956): e155-8. doi:10.1259/bjr/35049074 - Pubmed citation
- 6. Elharroudi T, Ismaili N, Errihani H et-al. Primary lymphoma of the ovary. J Cancer Res Ther. 4 (4): 195-6. J Cancer Res Ther (link) - Pubmed citation
- 7. Vang R, Medeiros LJ, Warnke RA et-al. Ovarian non-Hodgkin's lymphoma: a clinicopathologic study of eight primary cases. Mod. Pathol. 2001;14 (11): 1093-9. doi:10.1038/modpathol.3880442 - Pubmed citation
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