Progeria is a term used for any syndrome in which a person is prematurely aged, however, it most commonly refers to Hutchinson-Gilford progeria syndrome (HGPS).
Although the primary clinical manifestations of progeria include short stature and skin changes, the disease is associated with a variety of imaging manifestations 1,2:
- erosion of superior aspects of ribs
- osteolysis of distal clavicle
- Wormian bones
- rib notching
- periarticular soft tissue calcification
- premature atherosclerotic vascular calcification
History and etymology
The term "progeria" comes from the combination of "pro" (πρό), the greek word for "before" or "premature", and "gēras" (γῆρας), a term for "old age".
HGPS was first described by Jonathan Hutchinson in 1886 and independently by Hastings Gilford in 1897 1.