Pulmonary necrotizing granuloma refers to rather blanket term covering a group of entities which can result in granuloma formation with associated necrosis.
Pathology
On a pathologic specimen a necrotizing granuloma comprises of aggregates of macrophages transformed into epithelium-like cells surrounded by a collar of mononuclear leukocytes (principally lymphocytes and occasional plasma cells) with a surrounding area of necrosis.
They can result from both infectious and non-infectious causes.
According to a recent study, most of these were caused by unexplained etiology 1. Of the known etiologies, infectious causes tend to be more commoner.
The pathological spectrum includes:
- infectious
- non-infectious
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