Pulmonary non-tuberculous mycobacterial infection

Pulmonary non-tuberculous mycobacterial (NTM) infection refers to pulmonary infection caused by one of the large number (at least 150) mycobacterial species other than Mycobacterium tuberculosis. However, certain species are much more common than others.

Some patients are relatively asymptomatic. However, most have a combination of respiratory and systemic features similar to tuberculosis;

  • chronic cough
  • shortness of breath on exertion
  • hemoptysis
  • low-grade fever
  • night sweats
  • fatigue
  • weight loss

As with M. tuberculosis NTMs commonly cause pulmonary infection.

These organisms include:

The organisms have a predilection for individuals with pre-existing chronic obstructive pulmonary disease, with debilitating illnesses or various forms of immunocompromise.

Older age and tall slim Caucasian females seem to be more susceptible.

Gastro-esophageal reflux disease (GERD)

There may be an association achalasia of gastric cardia and M. fortuitum/chelonae infection.

Detailed guidelines on the management approach are available 12. The general principles are:

  • multidrug therapy according to the sensitivities of the organisms
  • treatment for at least 12 months
  • specialist follow-up to monitor compliance and drug side effects
     
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Article information

rID: 12129
System: Chest
Section: Gamuts
Synonyms or Alternate Spellings:
  • Non tuberculous mycobacterial infection (NTM)
  • Atypical mycobacterial infections
  • Pulmonary atypical mycobacterial infection
  • Non tuberculous mycobacterial infection
  • Non tuberculous mycobacterial (NTMB) infection
  • Atypical mycobacterial (ATM) infections
  • Non tuberculous mycobacterial infections
  • Pulmonary non tuberculous mycobacterial infection
  • Pulmonary non-tuberculous mycobacterial infection
  • Non tuberculous mycobacterial infection
  • Non tuberculous mycobacterial infection of lung
  • Pulmonary non tuberculous mycobacterial infections
  • Pulmonary nontuberculous mycobacterial infection

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Cases and figures

  • MAIC infection

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    Case 1: pulmonary MAIC infection
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