Pulmonary edema due to air embolism is one for the uncommon causes of non-cardiogenic pulmonary edema. It usually occurs as an iatrogenic complication of an invasive procedure. Rarely, it may also be associated with open or closed chest trauma.
Air may enter into the low-pressure venous system when a pressure gradient favors such access. This occurs most frequently during neurosurgical procedures 2,3 performed with the patient in the sitting position and during manipulation or placement of central venous lines.
Mechanical obstruction of the pulmonary microvasculature from embolized air bubbles can occur due to the relatively low absorption coefficient of air. These then create turbulent flow, which favors platelet aggregation, fibrin formation, and vasoconstriction, and increasing the pressure exerted on the vessel wall.
Non-mechanical factors such as the liberation of oxygen radicals from neutrophils may also contribute to the disruption of the capillary endothelium. Macromolecules, proteins, and blood cells may then enter the interstitial and alveolar spaces.
May be difficult to differentiate from other causes of non-cardiogenic pulmonary edema. Chest radiography may initially demonstrate an interstitial edema pattern followed by bilateral, peripheral alveolar areas of increased opacity with a basal predilection 1. There is no associated cardiomegaly, and the radiographic changes often rapidly disappear in patients who survive the acute event.
- 1. Gluecker T, Capasso P, Schnyder P et-al. Clinical and radiologic features of pulmonary edema. Radiographics. 19 (6): 1507-31. Radiographics (citation) - Pubmed citation
- 2. Frim DM, Wollman L, Evans AB et-al. Acute pulmonary edema after low-level air embolism during craniotomy. Case report. J. Neurosurg. 1996;85 (5): 937-40. doi:10.3171/jns.1996.85.5.0937 - Pubmed citation
- 3. Lam KK, Hutchinson RC, Gin T. Severe pulmonary oedema after venous air embolism. Can J Anaesth. 1993;40 (10): 964-7. doi:10.1007/BF03010100 - Pubmed citation
- 4. Cottrell JE, Young WL. Cottrell and Young's Neuroanesthesia. Mosby. (2010) ISBN:0323059082. Read it at Google Books - Find it at Amazon