Citation, DOI, disclosures and article data
Citation:
Weerakkody Y, Elfeky M, Di Muzio B, et al. Pulmonary talc granulomatosis. Reference article, Radiopaedia.org (Accessed on 19 Apr 2024) https://doi.org/10.53347/rID-25698
Pulmonary talc granulomatosis is one of the forms of talc-induced pulmonary disease and one of the excipient lung diseases. It is caused by talc particles mainly seen in patients injecting crushed methadone tablets intravenously.
As pulmonary talc granulomatosis is clinically and radiologically indistinct from patterns observed in response to other excipients such as microcrystalline cellulose, crospovidone, and starch, please refer to the main article on excipient lung diseases for further discussion regarding those aspects.
Pathology
It is characterized by the development of foreign body granuloma secondary to talc exposure.
The exact pathophysiological mechanism for this is not well known. Talc embolization is thought to result in initial inflammatory arteritis, associated with a rapid influx of neutrophils around talc particles. Migration of particles to the surrounding perivascular and pulmonary interstitial tissue with subsequent foreign body granuloma development.
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1. Low SE, Low SU, Nicol A. Talc induced pulmonary granulomatosis. J. Clin. Pathol. 2006;59 (2): 223. Free text at pubmed - Pubmed citation
-
2. Hollinger MA. Pulmonary toxicity of inhaled and intravenous talc. Toxicol. Lett. 1990;52 (2): 121-7. Pubmed citation
-
3. Krimsky WS, Dhand S. Pulmonary talc granulomatosis mimicking malignant disease 30 years after last exposure: a case report. J Med Case Rep. 2008;2 (1): 225. doi:10.1186/1752-1947-2-225 - Free text at pubmed - Pubmed citation
-
4. Restrepo CS, Carrillo JA, Martínez S et-al. Pulmonary complications from cocaine and cocaine-based substances: imaging manifestations. Radiographics. 2007;27 (4): 941-56. doi:10.1148/rg.274065144 - Pubmed citation
-
5. Flora GS, Sharma AM, Sharma OP. Talc granulomatosis: two unusual presentations. Sarcoidosis. 1994;8 (2): 136-9. Pubmed citation
-
6. Oubeid M, Bickel JT, Ingram EA et-al. Pulmonary talc granulomatosis in a cocaine sniffer. Chest. 1990;98 (1): 237-9. Pubmed citation
-
7. Ward S, Heyneman LE, Reittner P et-al. Talcosis associated with IV abuse of oral medications: CT findings. AJR Am J Roentgenol. 2000;174 (3): 789-93. doi:10.2214/ajr.174.3.1740789 - Pubmed citation
-
8. Genereux GP, Emson HE. Talc granulomatosis and angiothrombotic pulmonary hypertension in drug addicts. J Can Assoc Radiol. 1974;25 (2): 87-93. Pubmed citation
-
9. Muhammad Naeem, David H. Ballard, Hamza Jawad et-al. Noninfectious Granulomatous Diseases of the Chest. (2020) RadioGraphics. 40 (4): 1003-1019. doi:10.1148/rg.2020190180 - Pubmed
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