Quadrangular space syndrome

Last revised by Arlene Campos on 11 Jan 2024

Quadrangular space syndrome, also known as quadrilateral space syndrome, is an uncommon diagnosis mainly because of lack of literature on the subject and possible misdiagnosis.

Quadrangular space syndrome is present on ~1% of shoulder MRIs 6

Patients present with posterior shoulder pain and paresthesia over the lateral arm 5 due to an axillary nerve neuropathy. Shoulder pain may also be vague 7 and be associated with local tenderness. 

Quadrangular space syndrome is a neurovascular compression syndrome of the posterior humeral circumflex artery (PHCA) and/or the axillary nerve or one of its major branches in the quadrangular space.

Quadrangular space syndrome most commonly occurs when the neurovascular bundle is compressed by fibrotic bands within the narrow quadrangular space and/or by hypertrophy of the muscle boundaries. Fibrotic bands form as the result of trauma, with resultant scarring and adhesions. Cases reported in throwing athletes, tennis players, and in the dominant arm of volleyball players support the fibrosis and hypertrophy based hypotheses.

Other reported cases of quadrangular space syndrome include:

  • acute trauma, e.g. crush or traction injury 5

  • masses

    • ganglion cyst

    • paralabral cyst arising from a detached inferior glenoid labral tear

    • aneurysms and traumatic pseudoaneurysms of the posterior circumflex humeral artery

    • tumors, e.g. humeral osteochondroma, lipoma

Variation in axillary nerve division and a genetically smaller quadrangular space have been hypothesized to predispose to quadrangular space syndrome. This may account for the limited number of reported cases.

MRI is the investigation of choice but is often normal 7. MRI may demonstrate atrophy of the teres minor and/or deltoid muscles with or without fatty infiltration. A literature review has shown varying proportions of deltoid and teres minor involvement. Fibrous bands are usually not visible on MRI. In the presence of a mass, the neurovascular bundle may be displaced.

Before the advent of MRI, conventional angiography was the primary diagnostic modality. Angiography would show occlusion or compression of the posterior circumflex artery in the quadrangular space region, more pronounced when the arm is abducted. The neurovascular bundle may also be displaced.

Treatment is initially conservative if no cause is found. Refractory cases require surgery. If a definitive lesion is demonstrated on MR then primary surgery can be undertaken.

The identification of MRI findings of quadrangular space syndrome and the exclusion of other treatable abnormalities in the shoulder may allow the institution of appropriate nonsurgical therapy to be followed potentially by surgical treatment in some refractory cases. Even if other shoulder abnormalities are present, findings of quadrangular space syndrome may provide an explanation for some of the patients who have persistent discomfort after treatment of the primary shoulder abnormality.

On imaging consider:

  • disuse atrophy: will show multiple muscle involvement around the shoulder and not just teres minor/deltoid 

  • Parsonage-Turner syndrome: may be distinguished from quadrangular space syndrome on MRI by the usual involvement of more than one muscle or even more than one nerve distribution

ADVERTISEMENT: Supporters see fewer/no ads

Updating… Please wait.

 Unable to process the form. Check for errors and try again.

 Thank you for updating your details.