Raindrop skull

Last revised by Ashesh Ishwarlal Ranchod on 11 Jun 2023

The raindrop skull appearance of calvarial multiple myeloma is the presence of multiple, well-defined lytic lesions (punched out lesions) of various size scattered throughout the skull. This term is applied as an analogy to rain hitting a surface and splashing, where it leaves a random pattern of dark spots. 

Occasionally, the term is used synonymous (although inaccurately) with the pepper pot skull appearance of multiple lytic lesions of hyperparathyroidism 4.

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