Ranke complex (tuberculosis)

Ranke complex is seen in 'healed' primary pulmonary tuberculosis and is a later manifestation of the Ghon complex. It consists of two components:

  • a Ghon lesion that has undergone calcification
  • an ipsilateral calcified mediastinal node

History and etymology

Karl Ernest Ranke (1870-1926) was a German physician who developed the (now outdated) hypothesis on the pathology of pulmonary tuberculosis, which became known as "Ranke's stages of tuberculosis" 2.

Differential diagnosis

It should be noted that the imaging findings are completely non-specific. Sequelae of other granulomatous infections, such as healed thoracic histoplasmosis, can have identical imaging findings 3.

More rarely, a calcified or ossified lung metastasis 4 with ipsilateral hilar lymphadenopathy (e.g. from metastatic mucinous adenocarcinoma, osteosarcoma, or epithelial ovarian neoplasms 5) could give a similar imaging appearance.

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Article information

rID: 8645
System: Chest
Section: Signs
Tag: tb
Synonyms or Alternate Spellings:
  • Ranke's complex

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Cases and figures

  • Ranke complex
    Case 1: Ranke complex
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  • Ranke complex - H...
    Case 1: Ranke complex - HRCT
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  • Fig. 6

Coronal o...
    Case 2
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