Retro-odontoid pseudotumor

Retro-odontoid pseudotumors, also known as periodontoid pseudotumors, are non-neoplastic soft tissue masses adjacent to the odontoid process (dens) of C2, which can cause cervicomedullary compression.

The prevalence of retro-odontoid soft tissue thickening, particularly with mineralization presumed to represent calcium pyrophosphate deposition, increases significantly with age 1.

These are often asymptomatic. Acute inflammation in these masses (as in crowned dens syndrome) can manifest as neck pain or headache. As a chronic process, mass effect on the cervical spine can manifest as myelopathy including sensory and motor deficits.

Pseudotumors can arise by various mechanisms and etiologies 2,3:

The entity is defined by soft tissue thickening at the atlantoaxial junction around the expected location of the transverse atlantic ligament, posterior to the dens.

Mineralization within the pseudotumor may be present in calcium pyrophosphate deposition disease (chondrocalcinosis, linear/arciform), hydroxyapatite deposition disease (cloudlike), gout (faintly), fracture callus, and ossification of posterior longitudinal ligament (by definition).

Bony erosion may be present in rheumatoid arthritis, calcium pyrophosphate deposition disease, gout, and pigmented villonodular synovitis.

Signal characteristics vary by etiology. In general, there are no reliable imaging features that distinguish rheumatoid arthritis-related pannus from non-rheumatoid retro-odontoid pseudotumor.

  • T1: usually low
  • T2: variable, often heterogeneous

Consider:

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Article information

rID: 67025
Synonyms or Alternate Spellings:
  • Retroodontoid pseudotumour
  • Retro-odontoid pseudotumor
  • Peri-odontoid pseudotumor
  • Periodontoid pseudotumor

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Cases and figures

  • Case 1: CPPD on MRI
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  • Case 2: CPPD on CT
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  • Case 3: rheumatoid arthritis on MRI
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  • Case 4: rheumatoid arthritis on CT
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