Diagnostic HRCT criteria for usual interstitial pneumonia (UIP) pattern - ATS/ERS/JRS/ALAT (2018)

Last revised by Andrea Molinari on 12 Mar 2024

As a part of international evidence-based guidelines adopted by a collaborative effort of the American Thoracic Society (ATS), the European Respiratory Society (ERS), the Japanese Respiratory Society (JRS), and the Latin American Thoracic Association (ALAT), specific diagnostic HRCT criteria for usual interstitial pneumonia (UIP) pattern were adopted in 2011 and reviewed in 2018.

In 2018, the Fleischner Society has also published a white paper on the approach for the HRCT diagnosis of usual interstitial pneumonia: diagnostic HRCT criteria for usual interstitial pneumonia (UIP) pattern - Fleischner society guideline (2018)

  • the guideline is intended to help clinicians make an accurate diagnosis of IPF and to empower them to implement recommended courses of action, particularly decisions in which diagnostic intervention to pursue
  • the guideline applies for the patterns and distribution assessed on HRCT chest
  • these criteria have been shown to have moderate interobserver reliability among thoracic radiologists 4
  • UIP pattern (definite)
  • probable UIP pattern
  • indeterminate for UIP pattern
  • alternative diagnosis 

This helps radiologists to determine the certainty of usual interstitial pneumonia (UIP) diagnosis based on HRCT chest findings. The importance of this guideline is that (definite) UIP pattern on chest HRCT precludes the need for tissue diagnosis 1,2,5. However, unfortunately up to 20% of inconsistent with UIP group (or actually atypical UIP) can be UIP on biopsy or progress clinically to a diagnosis of idiopathic pulmonary fibrosis (IPF).

Classic HRCT pattern including:

  • honeycombing: it is the distinguishing feature of UIP and must be present
  • reticular abnormalities
  • distribution: subpleural with a basal predominance
  • absence of features suggestive of an alternative diagnosis 

HRCT studies with absent honeycombing, but showing:

  • reticular abnormalities 
    • +/- ground-glass opacification superimposed on a fine reticular pattern (cf. pure ground-glass opacities, which is not a typical UIP feature)
  • peripheral traction bronchiectasis or traction bronchiolectasis 
  • distribution: subpleural with a basal predominance
  • absence of features suggestive of an alternative diagnosis

HRCT features of pulmonary fibrosis that do not meet the "UIP" or "probable UIP" patterns above and does not explicitly suggest an "alternative diagnosis".

  • subtle reticular abnormalities 
    • +/- ground glass opacification superimposed on a fine reticular pattern (cf. pure ground-glass opacities, which is not a typical UIP feature)
  • distribution: do not suggest any specific etiology 

This category includes those patients with very limited subpleural reticulation or ground-glass opacities without other obvious features of pulmonary fibrosis and for whom there is some suspicion for an early UIP or probable UIP. 

Where imaging is performed with clinical suspicion for IPF, but HRCT findings are either suggestive of another etiology (e.g. hypersensitivity pneumonitis, NSIP, sarcoidosis) 5:

  • distribution
    • upper or mid lung predominance
    • peribronchovascular or perilymphatic
  • marked mosaic attenuation (air trapping), predominant ground-glass opacification
  • profuse micronodules, centrilobular nodules
  • pleural changes
    • effusions
    • thickening or plaques (consider asbestosis)

Other ancillary findings even in the presence of UIP pattern changes should prompt consideration of an alternative diagnosis: dilated esophagus (consider connective tissue disease), distal clavicular erosions (consider rheumatoid arthritis), extensive lymph node enlargement. 

In 2018 the guidelines were reviewed 5, and the main changes compared to the 2011 publication are:

  • "possible UIP" no longer exists and has been replaced by "probable UIP"
    • studies have shown that most of these patients were likely to have histopathologic UIP pattern despite the radiologic absence of honeycombing 
  • similar to the diagnostic HRCT criteria for usual interstitial pneumonia (UIP) pattern - Fleischner society guideline (2018), this reviewed guidelines moved from three to four HRCT categories with a reasonable correspondence among the two 2018 papers 
  • now, the patient's management should be based on their HRCT classification in two groups 5:
    • HRCT pattern of probable UIP, indeterminate for UIP, and alternative diagnosis
    • HRCT pattern of UIP

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