Right ventricular function is often measured in point-of-care ultrasonography as a composite of the right ventricular size, wall measurements, and contractile efforts.
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Terminology
The right ventricle (RV) can be anatomically divided into an inflow portion, an outflow portion, and an apex. Contraction of the right heart primarily occurs in a longitudinal manner, with radial and circumferential thickening playing a less important role than on the left. The right ventricular free wall accounts for most of the contractile power, and may be insonated most directly in the subcostal window. 5
Epidemiology
A dysfunctional right ventricle may be found in the following:
Pathology
Etiology
Common precipitants of right ventricular dysfunction include pressure overload, volume overload, ischemia, or a combination of all three. Examples include:
- acute pulmonary embolism
- right ventricular myocardial infarction
- pericardial tamponade
Radiographic features
The geometry of the right ventricle is more complex than that of the left ventricle (LV), anterior to and wrapping around the left ventricle. A global visual assessment of right ventricular function and size precede quantitative measurement 3. A normal right ventricle is two-thirds the size of the left ventricle, as measured in diastole.
Ultrasound
RV enlargement can be estimated using the “rule of thirds” in the parasternal long-axis view, or by comparing its size relative to that of the LV in the apical four-chamber view. The RV diameter does not normally exceed one-third the total ventricular width in the apical four-chamber view. Quantification of RV volumes and systolic function by echocardiography include the following indices:
-
tricuspid annular plane systolic excursion (TAPSE, normal >1.6 cm) 1
- the anteroposterior excursion of the tricuspid free annulus during systole
- obtained from the apical 4 chamber window, with an M-mode pick directed through the lateral tricuspid annulus
- a peak excursion of 1.5 cm or less is pathologic 6
-
right ventricular fractional area change (normal range 32-60%) 6
- assessed in a right ventricular optimized apical 4 chamber view at end diastole (RVEDA) and end-systole (RVESA) 2
- calculate the percentage of change with the equation (RVEDA-RVESA) / RVESA
- most cumbersome method to perform, but most accurate when compared to MRI measurements 4
- systolic excursion velocity (normal S' >10 cm/s)
- from an apical window, the tissue Doppler gate is placed on the lateral right ventricular wall, 1-2 cm above the tricuspid annulus
- S' corresponds to the peak of the positive inflection
Differential diagnosis
General imaging differential considerations for right ventricular dysfunction include:
- regional wall motion abnormalities 5
- the presence of regional wall motion abnormalities favors ischemia as the etiology
- global depression usually implies a non-ischemic mechanism
- free wall thickening
- right ventricular free wall thickness should never exceed 5 mm, as measured at end diastole
- wall thickening implies the presence of a chronic pressure overload, while a thin wall favors an acute process
- hyperdynamic apex
- previously thought to be specific for pulmonary embolism, McConnell's sign refers to the presence of akinesia of the mid free wall but normal motion at the apex 7
- present in other states of right ventricular strain, including right ventricular myocardial infarction 8