Sclerosing lobular hyperplasia (SLH) of the breast, also known as fibro-adenomatoid mastopathy, is an uncommon benign proliferative breast lesion.
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Epidemiology
It tends to occur more often in adolescent and young adult patients (peak age in the thirties). In the United States, there may be a greater incidence in African American women 2.
Clinical presentation
It often presents as a circumscribed mass and may or may not be palpable.
Pathology
It is histologically characterized by enlarged lobules (with prominent lobular hyperplasia) an increased number of intralobular ductules and sclerosis of the intralobular connective tissue.
Associations
- fibroadenoma: a fibroadenoma can have surrounding SLH in ~ 50% of cases 7
Radiographic features
Mammography
May present as a rounded radiodensity of variable size (1-8 cm 6) and may resemble a non-calcified fibroadenoma.
Breast ultrasound
Has a nonspecific sonographic appearance and may be seen as a lobular or oval-shaped mass with a circumscribed margin 5.
Differential diagnosis
General differential considerations include
- non calcified fibroadenoma: also as association
- well marginated breast neoplasm 6
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