Sepsis-associated encephalopathy (SAE) is a clinical term used to express a diffuse brain dysfunction, from mild delirium to deep coma, occurring secondary to sepsis without overt central nervous system infection. It usually occurs in critically ill patients in intensive care units, especially in those with severe systemic infection 1-3.
Sepsis-associated encephalopathy must be differentiated from septic-embolic encephalitis, which refers to a focal or diffuse brain infection, ischemic and hemorrhagic damages following an infective thromboembolism from any part of the body.
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- 3. Zhang QH, Sheng ZY, Yao YM. Septic encephalopathy: when cytokines interact with acetylcholine in the brain. Mil Med Res. 2014;1 (1): 20. doi:10.1186/2054-9369-1-20 - Free text at pubmed - Pubmed citation