Somatostatinomas are a rare type of neuroendocrine tumor. They may represent around 1% of all gastro-entero-pancreatic endocrine neoplasms.

Presentation can be variable. Patients with functional stomatostatinomas may present with an "inhibitory syndrome" which is a triad of mild diabetes mellitus, cholelithiasis, and diarrhea/steatorrhea. Other lesions can present with obstructive pancreatitis.

They typically occur in the pancreas but can also manifest in extrapancreatic organs (e.g. duodenum and papilla of Vater) and can result in chronic obstructive pancreatitis.

They may be functional (i.e patients have high fasting stomatostatin levels) or non functional. Functional somatostatinomas can release excessive amounts of somatostatin 2.

Smaller lesions may be difficult to diagnose. Described signal characteristics of larger lesioninclude

  • T1: low signal 1,8
  • T2: high signal 1,8
  • T1 (C+) Gd: most show early diffuse heterogenous enhancement

Most somatostatinomas are malignant and are often associated with regional and/or portal metastases at the time of diagnosis 7.

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rID: 37069
Synonyms or Alternate Spellings:
  • Somatostatinomas

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