Revision 5 for 'Spermatic cord liposarcoma'

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Spermatic cord liposarcoma

Spermatic cord liposarcoma is the most common malignant tumor of the spermatic cord. Most present as painless, slow-growing masses and can be mistaken for inguinal hernias. They are usually well-differentiated and spread by local extension. 


In a large population-based registry, the annual incidence of spermatic cord tumor (SCT) is 0.3 cases/million. 362 patients with SCT were identified, with histological subtypes of liposarcoma (46%), leiomyosarcoma (20%), histiocytoma (13%), and rhabdomyosarcoma (9%)3

Clinical presentation

Most present as painless, slow growing masses. They can be mistaken for inguinal hernia, hydrocele, or other paratesticular neoplasms. 


Most are low-grade and well-differentiated, and spread by local extension. High-grade tumors can can spread via hematogenous or lymphatic routes3

Radiographic features

CT and MRI provide greater characterization and staging information than ultrasound. Fat-containing tumor with variable amounts of soft tissue, nodularity, and septations. 

Treatment and prognosis

Standard surgical treatment includes high orchiectomy and resection of the tumor and spermatic cord. Lymph node dissection is occasionally performed. Chemotherapy and radiation therapy depend the tumor grade, stage, and risk of recurrence1

Differential diagnosis

Lipoma is the most common benign tumor of the spermatic cord, and much more common than liposarcoma (45% of paratesticular masses)3. Other malignant tumors of the spermatic cord include leiomyosarcoma, histiocytoma, and rhabdomyosarcoma. 

See also

Paratesticular lesions

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