Spinal astrocytoma

Spinal astrocytomas are the second most common spinal cord tumor, representing 40% of intramedullary tumors 3. They account for 60% of pediatric intramedullary tumors, making them the most common spinal cord tumor in children 6.

This article specifically relates to spinal astrocytomas. For a discussion on intracranial astrocytomas and for a general discussion of the pathology refer to the main article: astrocytomaPilocytic astrocytomas and pleomorphic xanthoastrocytomas are also discussed separately.

The peak incidence of spinal astrocytomas occurs in the third decade, with the mean age at presentation being ~30 years. Males are affected somewhat more commonly than females (M:F = 3:2) 5.

There is an increased incidence in neurofibromatosis type 1.

Clinical presentation is similar to that of other intramedullary spinal tumors, commonly consisting of pain, weakness, and sensory changes. Bowel and bladder dysfunction are uncommon.

Astrocytomas (both intracranial and spinal) arise from astrocytic glial cells. Spinal cord astrocytomas generally have a lower histologic grade than astrocytomas in the brain (see grading of astrocytomas):

  • adults
    • low-grade: 75%
    • anaplastic astrocytoma: 25%
    • glioblastoma: ~1%
  • pediatric
    • in children <3 years, 80% are grade I or II 5

All astrocytomas are characterized by hypercellularity and absence of a surrounding capsule. In contrast to cord ependymomas, a cleavage plane is not present in most intramedullary spinal astrocytomas.

High grade tumors are more commonly associated with leptomeningeal spread, overall seen in up to 60% of spinal cord glioblastomas 5.

Spinal astrocytomas usually span multiple segments in craniocaudal extent, with an average length of involvement of 4-7 vertebral body segments 5,7.

Regarding their specific spinal location:

Astrocytomas are typically intramedullary masses which diffusely expand the spinal cord. They usually span spinal multiple segments, as discussed above. Their slow outward growth tends to cause osseous remodeling of the spinal canal, which may be the only clue to their presence on x-ray or CT.

The radiographic appearance of the spine can be normal; however, osseous remodelling at the level of the tumor may be seen as posterior vertebral body scalloping or thinning of the pedicle or laminae. Patients may present with scoliosis, especially in children presenting with holocord involvement 5. However, these features are less common compared to spinal ependymomas.

Expansion of the spinal cord is frequently visible on CT, but can be subtle due to limited soft tissue contrast resolution. Lesion conspicuity may be better on a contrast-enhanced study.

Myelography may show non-specific multisegmental cord enlargement, and may result in a block to normal flow of contrast past the lesion, although this is more common with ependymoma. 

As astrocytomas arise from cord parenchyma (c.f. ependymomas that arise in the central canal), they typically have an eccentric location within the spinal cord.

They may be exophytic, and even appear largely extramedullary. They usually have poorly defined margins. Peritumoral edema is present in ~40%. Intratumoral cysts are present in ~20% and peritumoral cysts are present in ~15% 8. Unlike ependymomas, hemorrhage is uncommon. 

Reported signal characteristics include

  • T1: isointense to hypointense
  • T2: hyperintense
  • T1 C+ (Gd)
    • vast majority enhance (previously thought to be universally enhancing 8)
    • usually patchy enhancement pattern

Astrocytomas are generally faster growing than ependymomas and have a worse prognosis. 

Surgical excision is usually the treatment of choice; however, due to the infiltrative nature of astrocytomas, resection is almost always histologically incomplete.

Cord astrocytomas in children tend to be associated with a good prognosis, as they behave much like grade I cerebellar pilocytic astrocytomas and displace neural tissue rather than infiltrate it.

The main differential diagnosis is a spinal ependymoma. Certain imaging features may help to differentiate between the two, which are covered in this article:

  • ependymoma
    • more common in adults
    • scoliosis and bony remodelling more common
    • central location in spinal canal
    • well-circumscribed
    • hemorrhage is common
      • may rarely present as a subarachnoid hemorrhage
      • hemosiderin staining especially at the superior and inferior margins (so-called hemosiderin capping) is common
    • focal, intense homogeneous contrast enhancement
    • more frequent and more prominent cysts (intratumoral and polar)
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Article information

rID: 19274
Synonyms or Alternate Spellings:
  • Astrocytoma of the spinal cord
  • Spinal astrocytomas
  • Astrocytoma of spinal canal
  • Astrocytoma of the spinal canal
  • Astrocytomas of spinal canal
  • Astrocytomas of the spinal canal
  • Astrocytoma of spinal cord
  • Spinal cord astrocytoma
  • Astrocytomas of the spinal cord

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