Spinal schwannoma

Spinal schwannomas are benign nerve sheath tumors within the spinal canal, typically arising from spinal nerve roots. They are one of the two most common intradural extramedullary spinal tumors, representing 15-50% of such lesions.

This article specifically relates to spinal schwannomas. For a general discussion of schwannomas, refer to the main article: schwannoma.

They have a peak incidence in the fifth through seventh decades 10. There is no significant sex predilection.

The vast majority of spinal schwannomas are solitary and sporadic (95%) 10. However, there is an association with neurofibromatosis type 2 (NF2). In patients with NF2, almost all spinal nerve root tumors are schwannomas or mixed tumors. In a young adult without the NF2 mutation, the finding of multiple schwannomas may meet criteria for schwannomatosis.

As spinal schwannomas usually arise from the dorsal sensory roots, patients commonly present with pain. Radicular sensory changes also occur. Weakness is less common. Myelopathy may occur if the lesion is large.

Schwannomas are in most instances indistinguishable from neurofibromas. Refer to the article on spinal nerve sheath tumors for a discussion of their radiographic appearance.

The vast majority of spinal schwannomas are intradural extramedullary in location. Rarely (1%), intramedullary tumors are found 10

They are most frequently seen in the cervical and lumbar regions, far more frequently than in the thoracic spine.

In general, schwannomas appear as solid, well-defined, rounded lesions, often with associated adjacent bony remodelling. When large, they may either align themselves with the long axis of the cord, forming sausage-shaped masses that can extend over several levels, or may protrude out of the neural foramen, forming a dumbbell-shaped mass. 

Although neurofibromas and schwannomas can look identical, schwannomas are frequently associated with hemorrhage, intrinsic vascular changes (thrombosis, sinusoidal dilatation), cyst formation and fatty degeneration. These findings are rare in neurofibromas 8

Signal characteristics include 9:

  • T1: 75% are isointense, 25% are hypointense.
  • T2: more than 95% are hyperintense, often with mixed signal 
  • T1 C+: virtually 100% enhance

An exception to the above signal characteristics is melanotic schwannomas, which are T1 hyperintense and T2 hypointense.

Schwannomas are slow growing lesions but can nevertheless be debilitating. They almost never undergo malignant change. Surgery is the treatment of choice. Gross total resection is usually curative for patients with sporadic tumors. For patients with NF2, there is a high incidence of new tumor formation.

The main differentials are:

For a discussion of helpful distinguishing features, please refer to spinal nerve sheath tumors.

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Article information

rID: 4745
Synonyms or Alternate Spellings:
  • Spinal neurinoma
  • Spinal Schwannoma
  • Spinal neurilemmoma
  • Spinal schwannomas
  • Spinal neurilemmomas

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Cases and figures

  • Case 1
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  • T1 gad fat sat
    Case 2
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  • Case 3: intradural
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  • Case 14: giant lumbar schwannoma
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