Splenic hemangiomas, also known as splenic venous malformations, splenic cavernous malformations, or splenic slow flow venous malformations, while being rare lesions, are considered the second commonest focal lesion involving the spleen after simple splenic cysts 5,12 and the most common primary benign neoplasm of the spleen 6. They are usually found incidentally and have imaging appearances similar to hepatic hemangiomas.
Please refer to the main article for a general discussion on cavernous venous malformation.
It is important to note that according to newer nomenclature (ISSVA classification of vascular anomalies) these lesions are merely known as slow flow venous malformations. Having said that it is probably helpful in reports to include the word 'hemangioma' as this term is ubiquitous in the literature and most familiar to many clinicians. The remainder of this article uses the term 'splenic hemangioma' for consistency with the majority of the existing literature.
Their autopsy prevalence rate is thought to range around 0.1-14% 7-8,13. Most hemangiomas tend to be discovered in adults from mid-30s to mid-50s years of age 8.
The vast majority are asymptomatic and are incidentally discovered. Occasionally they may be associated with splenomegaly, abdominal pain, dyspnea, diarrhea, or constipation [ref needed].
Splenic hemangiomas are comprised of non-encapsulated non-neoplastic vascular channels of varying size ranging from capillary to cavernous, containing slow flowing blood. These vessels are lined with a single layer endothelium 2,8.
- splenic haemangiomatosis: the presence of multiple splenic hemangiomas
- splenic manifestations of a systemic angiomatosis syndrome such as
Most lesions tend to be small in size (< 2cm 12). Calcification if present, either central punctate or peripheral curvilinear, can be detected on radiographs or CT scans.
Hemangiomas can have a variety of sonographic appearances depending on their exact histological composition (i.e. hypo, iso or hyperechoic). The dominant pattern, however, is considered to be a homogeneous echotexture that is predominantly hyperechoic 11.
- usually does not demonstrate any intrinsic color flow (~80% of cases) 11,13
- contrast enhanced ultrasound: isoechogenicity to splenic parenchyma in all phases is the most frequent typical enhancement pattern of splenic hemangiomas observed on contrast-enhanced sonography 11
Unenhanced CT scans can show a low-attenuation mass; following IV contrast, the vascular channels show centripetal fill (from the periphery inward). Larger lesions can fill more slowly and may do so incompletely and inhomogeneously 2.
Reported signal characteristics of most hemangiomas are similar to hepatic hemangiomas and are 6,10:
- T1: iso to hypo-intense to normal splenic parenchyma
- T2: hyperintense to splenic parenchyma
- most demonstrate early nodular centripetal enhancement and uniform enhancement at delayed imaging
- smaller lesions may, however, show homogeneous enhancement on immediate post-contrast acquisitions remaining enhanced on delayed images 12
Nuclear imaging with 99mTc labeled red cells shows slow accumulation of activity in the lesion followed by slow washout. Nuclear scans with 99mTc labeled sulfur colloid usually show a photopenic defect due to the radionuclide accumulation being restricted to functional splenic tissue.
Treatment and prognosis
They are benign lesions and carry no malignant potential. Their natural course is very slow growth over time 8. Hemangiomas are generally not treated unless they are symptomatic or very large, with an increased risk of hemorrhage; treatment then is usually a splenectomy.
- hypersplenism 13
- spontaneous rupture with hemorrhage is a risk with larger lesions
- in some patients, they may cause the Kasabach-Merritt syndrome 8
- malignant degeneration (rare) 13
- 1. Mayne KM, Brown DC. Splenic haemangioma associated with splenomegaly and raised erythrocyte sedimentation rate. J. Clin. Pathol. 1989;42 (12): 1312. J. Clin. Pathol. (link) - Free text at pubmed - Pubmed citation
- 2. Disler DG, Chew FS. Splenic hemangioma. AJR Am J Roentgenol. 1991;157 (1): 44. AJR Am J Roentgenol (citation) - Pubmed citation
- 3. Katz DS, Wojtowycz AR, Markarian B. Splenic hemangioma. Detection on a technetium-99M MDP bone scan. Clin Imaging. 18 (4): 279-82. - Pubmed citation
- 4. Ros PR, Moser RP, Dachman AH et-al. Hemangioma of the spleen: radiologic-pathologic correlation in ten cases. Radiology. 1987;162 (1): 73-7. Radiology (abstract) - Pubmed citation
- 5. Duddy MJ, Calder CJ. Cystic haemangioma of the spleen: findings on ultrasound and computed tomography. Br J Radiol. 1989;62 (734): 180-2. doi:10.1259/0007-1285-62-734-180 - Pubmed citation
- 6. Elsayes KM, Narra VR, Mukundan G et-al. MR imaging of the spleen: spectrum of abnormalities. Radiographics. 25 (4): 967-82. doi:10.1148/rg.254045154 - Pubmed citation
- 7. Cooper SG, Strauss EB, Levine AH. Detection of noncalcified splenic hemangioma by radionuclide bone scan. J. Nucl. Med. 1989;30 (6): 1111-2. J. Nucl. Med. (link) - Pubmed citation
- 8. Hoeger PH, Helmke K, Winkler K. Chronic consumption coagulopathy due to an occult splenic haemangioma: Kasabach-Merritt syndrome. Eur. J. Pediatr. 1995;154 (5): 365-8. - Pubmed citation
- 9. Abbott RM, Levy AD, Aguilera NS et-al. From the archives of the AFIP: primary vascular neoplasms of the spleen: radiologic-pathologic correlation. Radiographics. 24 (4): 1137-63. doi:10.1148/rg.244045006 - Pubmed citation
- 10. Ramani M, Reinhold C, Semelka RC et-al. Splenic hemangiomas and hamartomas: MR imaging characteristics of 28 lesions. Radiology. 1997;202 (1): 166-72. Radiology (abstract) - Pubmed citation
- 11. Taibbi A, Bartolotta TV, Matranga D et-al. Splenic hemangiomas: contrast-enhanced sonographic findings. J Ultrasound Med. 2012;31 (4): 543-53. J Ultrasound Med (full text) - Pubmed citation
- 12. Luna A, Ribes R, Caro P et-al. MRI of focal splenic lesions without and with dynamic gadolinium enhancement. AJR Am J Roentgenol. 2006;186 (6): 1533-47. doi:10.2214/AJR.04.1249 - Pubmed citation
- 13. Lee HJ, Kim JW, Hong JH, Kim GS, Shin SS, Heo SH, Lim HS, Hur YH, Seon HJ, Jeong YY. Cross-sectional Imaging of Splenic Lesions: RadioGraphics Fundamentals | Online Presentation. (2018) Radiographics : a review publication of the Radiological Society of North America, Inc. 38 (2): 435-436. doi:10.1148/rg.2018170119 - Pubmed
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