Status epilepticus

Last revised by Rohit Sharma on 21 Feb 2024

Status epilepticus is an acute and prolonged seizure that persists for a sufficient length of time or is repeated frequently enough that recovery between attacks does not occur. It is a clinical emergency associated with high morbidity and mortality.

Status epilepticus is a broad term that encompasses prolonged seizures. Additional qualifiers to 'status epilepticus' may be used in treatment-refractory cases 11:

  • refractory status epilepticus: when first- and second-line treatments (including one non-benzodiazepine) have failed

  • super-refractory status epilepticus: when status epilepticus has continued or recurred despite therapy with general anesthesia for 24 hours or more

The estimated incidence of ~35 per 100,000, and it is more common in lower socioeconomic populations 1.

Although the definition of status epilepticus proposed by the International League Against Epilepsy (ILAE) does not provide a definite time-frame, the ILAE suggested operational time-frames after which a seizure will likely become continuous 8:

  • tonic-clonic status epilepticus: 5 minutes

  • focal status epilepticus with impaired consciousness: 10 minutes

  • absence status epilepticus: 15 minutes

Broad clinical categories of status epilepticus include 8,10:

In patients with a known history of seizures, common causes of a status epilepticus are changes in antiseizure medications or withdrawal syndrome. Approximately 50% of these events occur in patients without any history of epilepsy and are usually related to an underlying condition, such as 1,2:

  • stroke

  • hypoxia

  • metabolic derangement (e.g. hypoglycemia)

  • toxicity (e.g. drugs)

  • encephalitis

  • alcohol intoxication or withdrawal 

  • pregnancy-related (e.g. eclampsia)

  • infections accompanied by fever (the most important cause in children)

In most instances, unless one of the underlying conditions is visible (e.g. stroke), CT of the brain will be unremarkable. 

The most common changes seen relate to an increased T2 signal (best seen on FLAIR) with some swelling. These regions may demonstrate corresponding diffusion abnormalities, with increased DWI signal and in some instances reduced ADC values 3,6. These changes are believed to be due to excessive metabolic demands placed on tissues due to sustained seizure activity, resulting in vasogenic and/or cytotoxic edema. If severe enough, cell metabolism will fail resulting in eventual cell death 3,4

It is important to note that diffusion needs to be assessed on ADC maps and not DWI as it is not possible to confidently distinguish true diffusion restriction from T2 shine through on DWI images only. When T2 signal elevation is associated with significant (>10%) drop in ADC values, follow-up is likely to reflect permanent damage 3,6. In contrast, isolated T2 signal change, without ADC signal drop is likely to fully resolve 3.

Post-contrast T1 imaging is extremely variable, ranging from no enhancement to marked enhancement, which may be gyriform or leptomeningeal in distribution.

The locations involved are variable, including 3,5:

  • cerebral cortex and subcortical white matter

  • hippocampi and mesial temporal lobes

  • thalamus, particularly the pulvinar region 5

  • cerebellum 9

Management is complex and many institutions will have their own treatment algorithms or protocols. Broad principles include 12:

  • first aid

  • initiation of antiseizure medications

    • first-line: benzodiazepine

    • second-line: loading dose(s) of other non-benzodiazepine antiseizure medications (e.g. levetiracetam, sodium valproate, phenytoin, lacosamide, etc.)

    • third-line: intubation with antiseizure medication and/or anesthetic infusion(s) (e.g. midazolam, propofol, thiopentone, ketamine, phenobarbital, etc.)

  • concurrent management of the underlying cause if known and if possible

  • functional seizures (previously, psychogenic non-epileptic seizures)

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