Stewart-Treves syndrome
Updates to Article Attributes
Body
was changed:
Stewart-Treves syndrome refers to an angiosarcoma seen in the setting of lymphoedema 1.
It was classically attributed to lymphoedemas induced by radical mastectomy to treat breast cancer. Nowadays, we know that it can arise in chronically lymphoedematous regions of any cause 2.
The incidence is unknown, but studies have shown that it occurred in a rate between 0.03% and 0.45% in patients who survive at least 5 years after radical mastectomy 5,6.
Pathology
Etiology
It can arise from any cause of chronic lymphoedema 3,4:
- mastectomy induced lymphoedema
- Milroy disease
- congenital lymphoedema
- traumatic lymphoedema
- filarial lymphoedema
- elephantiasis nostras verrucosa
- idiopathic lymphoedema
PhysiopathologyPathophysiology
Chronic lymphoedema seems to induce a degree of local immunodeficiency that leads to oncogenesis 7.
Prognosis
Treatment and prognosis
The prognosis is very poor, because angiosarcomas are very aggressive tumors that frequently recur locally and often metastasize early.
-<p><strong>Stewart-Treves syndrome</strong> refers to an <a href="/articles/angiosarcoma">angiosarcoma</a> seen in the setting of <a href="/articles/lymphoedema">lymphoedema</a> <sup>1</sup>.</p><p>It was classically attributed to lymphoedemas induced by radical mastectomy to treat breast cancer. Nowadays, we know that it can arise in chronically lymphoedematous regions of any cause <sup>2</sup>. </p><p>The incidence is unknown, but studies have shown that it occurred in a rate between 0.03% and 0.45% in patients who survive at least 5 years after radical mastectomy <sup>5,6</sup>.</p><h5>Etiology</h5><p>It can arise from any cause of chronic lymphoedema <sup>3,4</sup>:</p><ul>- +<p><strong>Stewart-Treves syndrome</strong> refers to an <a href="/articles/angiosarcoma">angiosarcoma</a> seen in the setting of <a href="/articles/lymphoedema">lymphoedema</a> <sup>1</sup>.</p><p>It was classically attributed to lymphoedemas induced by <a title="Radical mastectomy" href="/articles/radical-mastectomy">radical mastectomy</a> to treat <a title="Breast cancer" href="/articles/breast-neoplasms">breast cancer</a>. Nowadays, we know that it can arise in chronically lymphoedematous regions of any cause <sup>2</sup>. </p><p>The incidence is unknown, but studies have shown that it occurred in a rate between 0.03% and 0.45% in patients who survive at least 5 years after radical mastectomy <sup>5,6</sup>.</p><h4>Pathology</h4><h5>Etiology</h5><p>It can arise from any cause of chronic lymphoedema <sup>3,4</sup>:</p><ul>
-<li>Milroy disease</li>- +<li><a title="Milroy disease" href="/articles/chronic-hereditary-lymphedema">Milroy disease</a></li>
-<li>filarial lymphoedema</li>-<li>elephantiasis nostras verrucosa</li>- +<li><a title="Filarial infection" href="/articles/filariasis">filarial lymphoedema</a></li>
- +<li><a title="Elephantiasis nostras verrucosa" href="/articles/elephantiasis-nostras-verrucosa">elephantiasis nostras verrucosa</a></li>
-</ul><h5>Physiopathology</h5><p>Chronic lymphoedema seems to induce a degree of local immunodeficiency that leads to oncogenesis <sup>7</sup>.</p><h5>Prognosis</h5><p>The prognosis is very poor, because angiosarcomas are very aggressive tumors that frequently recur locally and often metastasize early.</p><p> </p>- +</ul><h5>Pathophysiology</h5><p>Chronic lymphoedema seems to induce a degree of local immunodeficiency that leads to oncogenesis <sup>7</sup>.</p><h4>Treatment and prognosis</h4><p>The prognosis is very poor, because angiosarcomas are very aggressive tumors that frequently recur locally and often metastasize early.</p>
Unable to process the form. Check for errors and try again.