Revision 21 for 'Stewart-Treves syndrome'

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Stewart-Treves syndrome

Stewart-Treves syndrome refers to an angiosarcoma seen in the setting of lymphedema 1.

It was classically attributed to lymphedemas induced by radical mastectomy to treat breast cancer. Nowadays, we know that it can arise in chronically lymphedematous regions of any cause 2

The incidence is unknown, but studies have shown that it occurred in a rate between 0.03% and 0.45% in patients who survive at least 5 years after radical mastectomy 5,6.



It can arise from any cause of chronic lymphedema 3,4:


Chronic lymphedema seems to induce a degree of local immunodeficiency that leads to oncogenesis 7.

Treatment and prognosis

The prognosis is very poor because angiosarcomas are very aggressive tumors that frequently recur locally and often metastasize early.

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