Surgical sieve (mnemonic)

Last revised by Arlene Campos on 19 Jan 2024

A surgical sieve is an approach to differential diagnosis that prompts the user to consider various types of pathologies systematically. A surgical sieve does not need to be a mnemonic 2, although many find it easier to remember it when a mnemonic is used. Various versions of this mnemonic exist:

  • 5I 3-Scotland

  • MIDNIT

  • VINDICATE

  • VITAMIN CDEF

  • NAIVE MD DICTionary

Mnemonics

5I 3-Scotland

Where "3-Scotland" relates to the three top killers in Scotland.

  • I: infection

  • I: inflammation

  • I: immune

  • I: iatrogenic

  • I: idiopathic

  • 1: vascular/cardiovascular

  • 2: cancer

  • 3: trauma

MIDNIT

This mnemonic is used in one of the House M.D. episodes (Paternity):

  • M: metabolic

  • I: inflammation

  • D: degenerative

  • N: neoplastic

  • I: infection

  • T: trauma

VINDICATE
  • V: vascular

  • I: infection

  • N: neoplasm

  • D: degenerative or drugs

  • I: iatrogenic or intoxication

  • C: congenital

  • A: autoimmune

  • T: trauma

  • E: endocrine/metabolic

VITAMIN CDEF
  • V: vascular

  • I: infective

  • T: traumatic

  • A: autoimmune

  • M: metabolic

  • I: iatrogenic

  • N: neoplastic

  • C: congenital

  • D: degenerative

  • E: endocrine

  • F: functional

Some use a subset of the above, such as VITAMIN or VITAMIN CD.

NAIVE MD DICTionary
  • N: neoplastic

  • A: autoimmune/allergic (inflammatory)

  • I: infectious

  • V: vascular

  • E: environmental toxin exposure

  • M: metabolic (endocrine, nutritional, biochemical)

  • D: drugs

  • D: degenerative

  • I: iatrogenic (procedural/surgical)

  • C: congenital/developmental

  • T: traumatic

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